Interrupting anti-HIV treatment for an extended period and then re-initiating therapy might be safe in some patients, according to a study by Northwestern University infectious disease experts.
Chad Achenbach, M.D., and co-investigators from The Feinberg School of Medicine presented data from their research today at the XIV International AIDS Conference.
In an observational study, 25 HIV-infected patients with viral suppression for at least six months while receiving highly active antiretroviral therapy (HAART) interrupted treatment for an average of nine months.
None of the patients had HIV-related infections or illnesses during the interruption. All of the patients had increases in virus levels and drops in infection-fighting CD4 cells. Patients with lower virus levels prior to treatment and stronger immune systems responded more favorably during the interruption.
When HAART was resumed in 11 of the patients, they experienced maximal viral suppression and robust increases in CD4 cell counts.
Previous studies have examined whether treatment interruption could be used as a strategy for boosting immune response to HIV or reducing resistance to the medications. The current study focused on the effects of stopping HAART for longer periods to minimize complications of the therapy.
"We were surprised that so many patients were able to remain off their therapy for so long a period," Achenbach said.
"Extended treatment interruption appears safe and, after further study, may be an important HIV treatment strategy for the reduction of long-term toxicity, medication burden and expense," he said.
Auchenbach cautioned that not all patients should stop therapy, and that if patients do interrupt therapy, they should consult their physician.
Achenbachs co-researchers were Michele Till, M.D., assistant professor of medicine; Sophia Terp; Maria Deloria Knoll, M.D., research assistant professor of preventive medicine; Laura Colangelo; Kiang Liu, professor of preventive medicine; Frank Palella, M.D., assistant professor of medicine; Aleks Kalnins; and Robert L. Murphy, M.D., professor of medicine and director of HIV/AIDS clinical research at Northwestern University.
Elizabeth Crown | EurekAlert
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy