Depression investigators at The Research Institute of University Hospitals of Cleveland have zeroed in on the neurotransmitter serotonin, a brain chemical that regulates emotion. Their tactics: reduce serotonin levels in each study subject to learn who is vulnerable for developing major depression.
This new study, funded by the National Institute of Mental Health, is designed to help scientists better understand the role of serotonin in people who get major depression. By examining the way people feel when serotonin is briefly reduced, UHRI investigators hope to discover new ways of predicting who is at risk for major depression and when treatment with antidepressants can safely be discontinued, according to Pedro L. Delgado, MD.
Dr. Delgado, Chairman of the Department of Psychiatry at UHC and Case Western Reserve University, is the primary investigator for this study. In the study, tests are conducted on healthy participants and upon people having previously suffered from depression. Serotonin levels are temporarily reduced for up to 8 hours and the study team then carefully monitors how the participant feels.
Eric Sandstrom | EurekAlert
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