Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Easier to predict the future for leukemia patients

20.02.2008
Researchers at Umeå University in Sweden are showing that the length of telomeres in leukemia cells is tied to specific genetic aberrations and is an independent diagnostic marker that can tell us something about the future prospects for leukemia patients.

A research team directed by Professor Göran Roos at the Department of Medical Bioscience, Pathology, is behind the study, which is now being published in the journal Blood.

The study, carried out in collaboration with colleagues at Ulm University, Germany, and at Uppsala University, Sweden, shows that the length of telomeres in chronic lymphatic leukemia (CLL) cells is tied to specific genetic aberrations of known prognostic significance.

Cases with no chromosome 17p or 11q evinced short telomeres, while cases with no 13q had significantly longer telomeres. Other known prognostic factors, such as the number of mutations in immunoglobulin genes, expression of the proteins ZAP70 and CD38, and clinical stage, were all significantly associated with telomere length as well. It was interesting that telomere length proved to be a prognostic marker that is independent of all of these factors. In other words, it can tell us more about the future prospects of leukemia patients than previously known markers are able to.

The tips of chromosomes, telomeres, are important for the genetic stability of our cells. In normal cells, telomeres are shortened each time the cell divides, whereas cancer cells usually have stable telomere length. This stability helps lend cancer cells 'eternal' life. The telomere length of a cell is determined by a balance between positive and negative factors, many of which are unknown. Short telomeres have been shown to be tied to unstable genes. This research team has previously demonstrated that patients with CLL where the leukemia cells evince short telomeres (reduced median length) have a significantly poorer prognosis than patients with long telomeres (Grabowski et al. 2005; Blood, 105(12):4807-12).

For more information, please contact Professor Göran Roos, Department of Medical Bioscience, Section for Pathology, phone: +46 (0)90-785 18 01, e-mail goran.roos@medbio.umu.s.

A high-resolution picture of Göran Roos can be downloaded from
http://www.umu.se/medfak/aktuellt/bilder/index.html
Reference: Roos G, Kröber A, Grabowski P, Kienle D, Bühler A, Döhner H, Rosenquist R, Stilgenbauer S. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood. 2008 Feb 15;111(4):2246-52. http://bloodjournal.hematologylibrary.org/cgi/content/full/111/4/2246

Commentary: Lin TS. Do short telomeres shorten CLL survival? Blood, 15 February 2008, Vol. 111, No. 4, pp. 1755.

Bertil Born | Umeå University
Further information:
http://bloodjournal.hematologylibrary.org/cgi/content/full/111/4/2246
http://www.umu.se/medfak/aktuellt/bilder/index.html

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>