Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Polymer gel prevents skin grafts from shrinking

25.01.2008
A gel that could prevent the painful and disfiguring contractions of skin grafts used to treat burns has been developed by British scientists.

When skin is irreparably damaged by burns, skin taken from other areas of the patient’s body – or created by tissue engineering – is grafted onto the burned area. Although grafts often heal successfully, the skin shrinks significantly in nearly a third of patients. The process is painful and disabling, and particularly common in children.

Karima Bertal and colleagues at the University of Sheffield have now developed an enzyme-inhibiting drug which can halve this contraction, and loaded it into a biocompatible polymer gel to smear onto the graft. Bertal presented the group’s preliminary results at the Royal Society of Chemistry’s Biomaterials conference in Manchester, UK, earlier this month.

Sheila MacNeil, the scientist who leads the research, told Chemistry World that currently the only accepted treatment for graft contraction is to have the patient wear pressure garments – extremely tight clothing that pushes down on the dermis to prevent it forming bumps of contracted tissue.

Her research team found that an enzyme called lysyl oxidase is involved in causing the graft contraction, as it ties together collagen fibres in the deep dermal layer of the skin. Then they identified a compound that inhibits the enzyme, called 3-aminopropionitrile, and combined it with a biocompatible polymer gel invented by chemist Steve Armes, also at Sheffield.

Tests of the drug on human skin samples were successful: ‘The control grafts contract to about 60 per cent of their original size, but [when the drug is applied] they only contract down to 80 per cent,’ Bertal told Chemistry World.

The gel also works as they hoped: ‘Our polymer gel is well tolerated by the skin and releases the drug in a controlled manner over about 48 hours,’ she said.

The team has now started testing the drug-gel combination itself on human skin samples, and early results looks promising, said MacNeil. ‘If they’re successful, we would like to move into the clinic,’ she said.

Brian Emsley | alfa
Further information:
http://www.rsc.org
http://www.rsc.org/chemistryworld/News/2008/January/24010801.asp

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Early organic carbon got deep burial in mantle

25.04.2017 | Earth Sciences

A room with a view - or how cultural differences matter in room size perception

25.04.2017 | Life Sciences

Warm winds: New insight into what weakens Antarctic ice shelves

25.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>