Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein in saliva promises new diagnostic methods

31.05.2012
Blood poisoning is a serious problem in medical care. Research from Malmö University in Sweden now shows that the protein suPAR, which can be used for early detection of critical cases of sepsis, is found in saliva, which opens new potential for tracking diseases.

Blood poisoning, or sepsis, affects about 0.2 percent of the population. It is a serious condition that can lead to septic shock, one of the most common causes of death at Swedish intensive care units. There is therefore a great need for early identification of potentially critical cases among patients.

SuPAR a good marker

The protein suPAR can be used as a marker of blood poisoning. This is shown in a dissertation written by Anna Gustafsson, a doctoral candidate at Malmö University. Gustafsson also found that the protein correlates with the so-called SOFA score, a measure of organ failure that is used in cases of blood poisoning. The protein could thus be used to identify patients who risk developing serious disease.

“Today a number of analyses are put together to identify these patients. It would be much easier and quicker to use suPAR, because only one sample is needed,” she says.

Opens new avenues
Gustafsson is also the first researcher to study the occurrence of suPAR in saliva and has found that the concentration of the protein is ten times higher than in the blood.

“We know that saliva reflects the composition of blood. The fact that suPAR in the blood can indicate cancer, diabetes, and other serious diseases means that our findings could open entirely new avenues for tracking various diseases in saliva,” says Gustafsson.

Using saliva instead of blood samples is of great value in screening studies, as samples can be acquired with little bother to patients, who in fact can take the sample themselves at home.

Treatment with peptides
Medical care needs not only better diagnostic methods but also more effective treatment for blood poisoning. In her research Gustafsson has studied how antimicrobial peptides, AMPs, affect two different bacterial toxins, LPS and LTA.

“The results show that AMPs moderate the immune defense’s reaction to LPS but strengthen the reaction to LTA. This is a truly unexpected finding, which hypothetically could mean that peptide treatment of LTA might aggravate the condition,” says Gustafsson.

For further information please contact Anna Gustafsson; Telephone: +46 40-66 57416 or mobile phone: +46 70 – 53 46 645 or E-mail: anna.gustafsson@mah.se

Charlotte Löndahl Bechmann | idw
Further information:
http://www.vr.se

Further reports about: AMPs LPS LTA Protein bacterial toxin blood poisoning blood sample serious disease

More articles from Health and Medicine:

nachricht Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>