Blood poisoning, or sepsis, affects about 0.2 percent of the population. It is a serious condition that can lead to septic shock, one of the most common causes of death at Swedish intensive care units. There is therefore a great need for early identification of potentially critical cases among patients.
SuPAR a good marker
The protein suPAR can be used as a marker of blood poisoning. This is shown in a dissertation written by Anna Gustafsson, a doctoral candidate at Malmö University. Gustafsson also found that the protein correlates with the so-called SOFA score, a measure of organ failure that is used in cases of blood poisoning. The protein could thus be used to identify patients who risk developing serious disease.
“Today a number of analyses are put together to identify these patients. It would be much easier and quicker to use suPAR, because only one sample is needed,” she says.Opens new avenues
“We know that saliva reflects the composition of blood. The fact that suPAR in the blood can indicate cancer, diabetes, and other serious diseases means that our findings could open entirely new avenues for tracking various diseases in saliva,” says Gustafsson.
Using saliva instead of blood samples is of great value in screening studies, as samples can be acquired with little bother to patients, who in fact can take the sample themselves at home.Treatment with peptides
“The results show that AMPs moderate the immune defense’s reaction to LPS but strengthen the reaction to LTA. This is a truly unexpected finding, which hypothetically could mean that peptide treatment of LTA might aggravate the condition,” says Gustafsson.
For further information please contact Anna Gustafsson; Telephone: +46 40-66 57416 or mobile phone: +46 70 – 53 46 645 or E-mail: firstname.lastname@example.org
Charlotte Löndahl Bechmann | idw
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