The findings were presented at the Heart Failure Congress 2012, 19-22 May, in Belgrade, Serbia. The Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology.
Obesity is a risk factor for cardiovascular disease, and previous research has shown that obese adults have structural and functional changes to their hearts. The current study (abstract P843) investigated the relationship between body mass index (BMI) and cardiac function in overweight and obese adolescents with no symptoms of heart disease.
For the study, 97 healthy adolescents had their weight, height, waist circumference and hip circumference measured. BMI and waist/hip ratio were calculated. Blood and biochemistry tests and an echocardiogram were performed. Based on their BMI, patients were divided into three groups: lean (L=32 patients), overweight (Ov=33 patients) and obese (Ob=32 patients).
Several measures of heart size were made using information from the echocardiogram. Interventricular septal and left ventricular posterior wall thickness increased as BMI increased (L: 0.84+0.1 cm, Ov: 0.88+0.1 cm, Ob: 0.96+0.1cm, p=0.001; and L: 0.78+0.1 cm, Ov: 0.8+0.1 cm, Ob: 0.94+0.1cm, p=0.001, respectively).
Relative wall thickness and left ventricular mass index also increased in parallel to BMI (L: 0.34+0.05, Ov: 0.34+0.05, Ob: 0.40+0.04, p=0.001; and L: 47.7+8.4 g/m2, Ov: 51.9+8.3 g/m2, Ob: 65.2+13.3 g/m2, p=0.001, respectively).
Measures of heart function were also performed. Left ventricular early diastolic lateral and septal velocities were reduced only in obese adolescents (L: 15.3+3.9cm/s, Ov: 13.6+4 cm/s, Ob: 10.5+3.4 cm/s, p=0.001; and L: 12.2+2.3 cm/s, Ov: 11.1+2.4 cm/s, Ob: 9.8+3.1 cm/s, p=0.003, respectively).
Systolic velocities were also only reduced in obese adolescents (L: 9.2+1.4cm/s, Ov: 9.3+2.3 cm/s, Ob: 8.04+1.5 cm/s, p = 0.018; and L: 9.05+2.3 cm/s, Ov: 9+2.4 cm/s, Ob: 7.6+1.1 cm/s, p=0.014, respectively).
Left ventricular lateral diastolic (r=-0.44, p=0.001) and systolic (r=-0.29, p=0.005) velocities correlated with BMI.
Obese adolescents with no symptoms of heart disease had damaged hearts with thicker walls. The systolic and diastolic function of their hearts was also impaired. Both structural and functional measures correlated with BMI. These findings may explain why obesity is a risk for heart disease.
"Education on healthy food and exercise is needed in schools to prevent obesity and early cardiovascular disease in adolescents," says lead author Professor Gani Bajraktari, professor of internal medicine and cardiology at the University of Pristina in Kosovo. "This is an important step in preventing obesity and cardiovascular disease in adults."
More studies are needed to show whether the heart damage in obese adolescents can be reversed if they lose weight.References
Heart Failure2012 is the annual meeting of Heart Failure Association (HFA) a registered branch of the European Society of Cardiology (ESC). HeartFailure2012 takes place 19 to 22 May 2012 at Sava Centar, Belgrad – Serbia. The full scientific programme is accessible here.About Heart Failure 2012 Registration
ESC Press Office | EurekAlert!
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy