Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NIH scientists discover promising target to block Staphylococcus infection

11.02.2013
National Institutes of Health (NIH) scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, a bacterium that frequently resists traditional antibiotics.

The researchers discovered a system used by S. aureus to transport toxins that are thought to contribute to severe staph infections. These toxins—called phenol-soluble modulins (PSMs)—have gained much attention in recent years, but their multitude and diversity have hindered efforts to target them for drug development.

Expanding on work that first described S. aureus PSMs in 2007, scientists at the NIH's National Institute of Allergy and Infectious Diseases found that the transport system, which they call Pmt, is common to all S. aureus PSMs and critical for bacterial proliferation and disease development in a mouse model. Their experiments suggest that a drug interfering with Pmt's function could not only prevent production of the PSM toxins, but also directly lead to bacterial death.

Although their study focused on S. aureus, the scientists suspect that Pmt performs the same role in other staphylococci, such as S. epidermidis, the leading cause of hospital-associated infections involving indwelling medical devices such as catheters, pacemakers and prosthetics. They plan to continue their studies to improve the understanding of how PSMs function and to learn how to interfere with the Pmt transport system to block disease.

ARTICLES:
S Chatterjee et al. Essential Staphylococcus aureus toxin export system. Nature Medicine DOI: 10.1038/nm3047 (2013).

R Wang et al. Identification of novel cytolytic peptides as key virulence determinants of community-associated MRSA. Nature Medicine DOI: 10.1038/nm1656 (2007).

Michael Otto, Ph.D., senior investigator, Laboratory of Human Bacterial Pathogenesis, NIAID. Dr. Otto is an expert in the molecular basis of pathogenesis in staphylococci.

CONTACT: To schedule interviews, please contact Ken Pekoc, (301) 402-1663, kpekoc@niaid.nih.gov.

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health

Ken Pekoc | EurekAlert!
Further information:
http://www.niaid.nih.gov
http://www.nih.gov

More articles from Health and Medicine:

nachricht Second-hand e-cig smoke compared to regular cigarette smoke
29.08.2014 | University of Southern California

nachricht Protein in 'good cholesterol' may be a key to treating pulmonary hypertension
28.08.2014 | University of California - Los Angeles Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

IT security in the digital society

27.08.2014 | Event News

Understanding the brain—neuroscientists meet in Göttingen

27.08.2014 | Event News

MEDICA EDUCATION CONFERENCE: Bessere Behandlung dank Biomarker

21.08.2014 | Event News

 
Latest News

Study finds marine protected areas inadequate for protecting fish and ocean ecology

29.08.2014 | Ecology, The Environment and Conservation

Trash Burning Worldwide Significantly Worsens Air Pollution

29.08.2014 | Ecology, The Environment and Conservation

Watching the structure of glass under pressure

29.08.2014 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>