Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Model predicts blood glucose levels 30 minutes later

26.03.2014

A mathematical model created by Penn State researchers can predict with more than 90 percent accuracy the blood glucose levels of individuals with type 1 diabetes up to 30 minutes in advance of imminent changes in their levels -- plenty of time to take preventative action.

"Many people with type 1 diabetes use continuous glucose monitors, which examine the fluid underneath the skin," said Peter Molenaar, Distinguished Professor of Human Development and Family Studies and of psychology.

"But the glucose levels under the skin trail blood glucose levels from anywhere between 8 and 15 minutes. This is especially problematic during sleep. Patients may become hypoglycemic well before the glucose monitor alarm tells them they are hypoglycemic, and that could lead to death."

According to Molenaar, a person's blood glucose levels fluctuate in response to his or her insulin dose, meal intake, physical activity and emotional state. How great these fluctuations are depends on the individual.

"In the past decade, much progress has been made in the development of a mechanical 'artificial pancreas,' which would be a wearable or implantable automated insulin-delivery system consisting of a continuous glucose monitor, an insulin pump and a control algorithm closing the loop between glucose sensing and insulin delivery," he said.

"But creating an artificial pancreas that delivers the right amount of insulin at the right times has been a challenge because it is difficult to create a control algorithm that can handle the variability among individuals. Our new model is able to capture this variability. It predicts the blood glucose levels of individuals based on insulin dose and meal intake."

The researchers created a time-varying model estimated by the extended Kalman filtering technique. This model accounts for time-varying changes in glucose kinetics due to insulin and meal intake.

The team tested the accuracy of its model using an FDA-approved UVa/Padova simulator with 30 virtual patients and five living patients with type 1 diabetes. The results appeared online this week in the Journal of Diabetes Science and Technology.

"We learned that the dynamic dependencies of blood glucose on insulin dose and meal intake vary substantially in time within each patient and between patients," said Qian Wang, professor of mechanical engineering.

"The high prediction fidelity of our model over 30-minute intervals allows for the execution of optimal control of fast-acting insulin dose in real time because the initiation of insulin action has a delay of less than 30 minutes. Our approach outperforms standard approaches because all our model parameters are estimated in real time. Our model's configuration of recursive estimator and optimal controller will constitute an effective artificial pancreas."

###

Other authors on the paper include Saurabh Harsh, graduate student in mechanical engineering; Kenneth Freeman, research assistant in mechanical engineering; Jinyu Xie, graduate student in mechanical engineering; Jing Zhou, graduate student in mechanical engineering; Carol Gold, research scientist in human development and family studies; Mike Rovine, professor of human development and family studies; and Jan Ulbrecht, professor of biobehavioral health and medicine.

The National Institutes of Health, the National Science Foundation and the Penn State Center for Clinical and Translational Science Institute supported this research.

A'ndrea Elyse Messer | EurekAlert!
Further information:
http://www.psu.edu

Further reports about: Technology algorithm artificial blood continuous levels pancreas skin variability

More articles from Health and Medicine:

nachricht Proteomics and precision medicine
08.02.2016 | University of Iowa Health Care

nachricht Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
02.02.2016 | eLife

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: From allergens to anodes: Pollen derived battery electrodes

Pollens, the bane of allergy sufferers, could represent a boon for battery makers: Recent research has suggested their potential use as anodes in lithium-ion batteries.

"Our findings have demonstrated that renewable pollens could produce carbon architectures for anode applications in energy storage devices," said Vilas Pol, an...

Im Focus: Automated driving: Steering without limits

OmniSteer project to increase automobiles’ urban maneuverability begins with a € 3.4 million budget

Automobiles increase the mobility of their users. However, their maneuverability is pushed to the limit by cramped inner city conditions. Those who need to...

Im Focus: Microscopy: Nine at one blow

Advance in biomedical imaging: The University of Würzburg's Biocenter has enhanced fluorescence microscopy to label and visualise up to nine different cell structures simultaneously.

Fluorescence microscopy allows researchers to visualise biomolecules in cells. They label the molecules using fluorescent probes, excite them with light and...

Im Focus: NASA's ICESat-2 equipped with unique 3-D manufactured part

NASA's follow-on to the successful ICESat mission will employ a never-before-flown technique for determining the topography of ice sheets and the thickness of sea ice, but that won't be the only first for this mission.

Slated for launch in 2018, NASA's Ice, Cloud and land Elevation Satellite-2 (ICESat-2) also will carry a 3-D printed part made of polyetherketoneketone (PEKK),...

Im Focus: Sinking islands: Does the rise of sea level endanger the Takuu Atoll in the Pacific?

In the last decades, sea level has been rising continuously – about 3.3 mm per year. For reef islands such as the Maldives or the Marshall Islands a sinister picture is being painted evoking the demise of the island states and their cultures. Are the effects of sea-level rise already noticeable on reef islands? Scientists from the ZMT have now answered this question for the Takuu Atoll, a group of Pacific islands, located northeast of Papua New Guinea.

In the last decades, sea level has been rising continuously – about 3.3 mm per year. For reef islands such as the Maldives or the Marshall Islands a sinister...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AKL’16: Experience Laser Technology Live in Europe´s Largest Laser Application Center!

02.02.2016 | Event News

From intelligent knee braces to anti-theft backpacks

26.01.2016 | Event News

DATE 2016 Highlighting Automotive and Secure Systems

26.01.2016 | Event News

 
Latest News

Ocean acidification makes coralline algae less robust

08.02.2016 | Earth Sciences

Online shopping might not be as green as we thought

08.02.2016 | Studies and Analyses

Proteomics and precision medicine

08.02.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>