Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Minimally invasive treatment found effective for esophageal cancer

02.09.2009
Esophageal cancer increasing faster than other malignancies

Researchers have found that early stage cancers of the esophagus can be treated as effectively by less-invasive, organ-sparing endoscopic therapy as compared to more complex surgical removal of the esophagus, according to a Mayo Clinic study published in the September 2009 issue of Gastroenterology.

In 20 percent of esophageal cancer (http://www.mayoclinic.org/esophageal-cancer) cases in the United States, the cancer is detected in the early stages," says Ganapathy Prasad, M.D., (http://www.mayoclinic.org/bio/12948837.html) gastroenterologist and lead author on the study. "Traditionally, esophageal cancer patients undergo a complicated surgery to remove the esophagus. Our team compared surgery to the use of endoscopic therapy, where a scope is inserted in the esophagus and the cancer cells are shaved off. Our results showed the less-invasive therapy was just as effective as surgery for early-stage cancers."

In this study of 178 patients with early-stage esophageal adenocarcinoma, 132 (74 percent) were treated with endoscopic mucosal resection and 46 (26 percent) were treated surgically. The endoscopic mucosal resection patients underwent a procedure where a liquid is injected under the lesion and then an endoscope is used to shave off the lesions. The other patients underwent more traditional esophagectomy or removal of the esophagus.

In following these patients for nine years, both groups had a comparable overall mortality rate of approximately 20 percent. Cancer recurred in 12 percent of patients treated endoscopically, but recurrence could be re-treated endoscopically.

Dr. Prasad explains that esophagectomy surgery patients are typically in the hospital for a week, and 30 to 50 percent of patients have complications post surgery. For example, patients whose esophagus has been removed face lifelong dietary restrictions. Endoscopic treatments, however, are performed in an outpatient care setting, and patients can eat full meals in a couple of days.

"If patients do choose to proceed to surgery, they should be advised to seek out a high-volume surgical center," says Kenneth Wang, M.D., (http://www.mayoclinic.org/bio/10031251.html) gastroenterologist and senior researcher on the study. "Research has shown that high-volume hospitals, such as Mayo Clinic, have better survival rates and outcomes for patients."

The Mayo Clinic Barrett's Esophagus Unit (http://www.mayoclinic.org/barretts-esophagus/rsttreatment.html) offers a multidisciplinary approach to evaluate early symptoms, devise a surveillance schedule and perform all tests and medical and surgical treatments.

Esophageal cancer arising from Barrett's esophagus is increasing in frequency faster than any other cancer in the United States, and the tumor is lethal. Ninety percent of patients die within five years of diagnosis. About 10 percent of patients with chronic acid reflux develop the tissue changes characteristic of Barrett's esophagus, which can lead to cancer.

Dr. Wang says that future research in this area will examine genetic markers to help determine the best course of treatment for esophageal cancer patients. In addition, the Mayo research team hopes to study the use of endoscopic therapy for more advanced esophageal cancers.

Mayo Clinic's Division of Gastroenterology and Hepatology (http://www.mayoclinic.org/gi/) has been ranked #1 in the U.S. News & World Report Honor Roll of Top Hospitals since the rankings began 20 years ago.

Other members of the Mayo research team included Tsung-Teh Wu, M.D., Ph.D.; (http://www.mayoclinic.org/bio/12139416.html) ; Dennis Wigle, M.D., Ph.D. (http://www.mayoclinic.org/bio/14807335.html/); Navtej Buttar, M.D., (http://www.mayoclinic.org/bio/12404888.html); Louis-Michel Wongkeesong, M.D., Kelly Dunagan, Lori Lutzke and Lynn Borkenhagen.

About Mayo Clinic

Mayo Clinic is the first and largest integrated, not-for-profit group practice in the world. Doctors from every medical specialty work together to care for patients, joined by common systems and a philosophy of "the needs of the patient come first." More than 3,300 physicians, scientists and researchers and 46,000 allied health staff work at Mayo Clinic, which has sites in Rochester, Minn., Jacksonville, Fla., and Scottsdale/Phoenix, Ariz. Collectively, the three locations treat more than half a million people each year. To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. For information about research and education, visit www.mayo.edu. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories.

Amy Tieder | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Organ-on-a-chip mimics heart's biomechanical properties

23.02.2017 | Health and Medicine

Light-driven reaction converts carbon dioxide into fuel

23.02.2017 | Life Sciences

Oil and gas wastewater spills alter microbes in West Virginia waters

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>