Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Mechanism of HIV spread has potential for future drug therapy

A new understanding of the initial interactions of human immunodeficiency virus type 1 (HIV-1) and dendritic cells is described by Boston University School of Medicine (BUSM) researchers in a study currently featured in the Proceedings of the National Academy of Sciences (PNAS).
With over 2.5 million new HIV infections diagnosed annually and earlier detection becoming more common, better understanding of early virus-host interactions could have a great impact on future research and drug therapy.

In this study, the researchers describe a novel mechanism of HIV-1 spread by dendritic cells. These cells, which are present at the body's mucosal surfaces, are the focus of research because they are among the first cells to encounter HIV-1 and trigger the immune system. While previous work has focused on the HIV-1 envelope glycoprotein method of interactions, this research details the role of a molecule called GM3, which arises from the host itself and is used by the virus for attachment and spread.

Since this virus invasion method depends on the molecules originating from the host, "it is a stealth entry mechanism, likely not detected by the cell, so HIV can spread quickly," says Dr. Rahm Gummuluru, associate professor in the department of microbiology at BUSM and senior author of the study.

Despite the cleverness of the virus, this unique contact between HIV-1 and dendritic cells may offer a new direction for anti-viral therapies. "Resistance to therapy, which often challenges physicians, is unlikely to occur in drugs that target this interaction, as these drugs would have the benefit of acting on the host, instead of the virus," Gummuluru. Further research in this field may identify specific targets and offer hope for preventing HIV infections.

The research was led by Dr. Wendy Blay Puryear, post-doctoral fellow in the department of microbiology at BUSM, in collaboration with Dr. Björn Reinhard, assistant professor of chemistry and the photonics center at Boston University.

Gina DiGravio | EurekAlert!
Further information:

Further reports about: BUSM HIV HIV infection HIV-1 dendritic cells mechanism microbiology photonics center

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>