Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lower autism risk with folic acid supplements in pregnancy

13.02.2013
Women who took folic acid supplements in early pregnancy almost halved the risk of having a child with autism.

Beginning to take folic acid supplements later in pregnancy did not reduce the risk. This is shown in new findings from the ABC Study and Norwegian Mother and Child Cohort Study published in the Journal of The American Medical Association (JAMA).

Women who took folic acid supplements from four weeks before conception to eight weeks into pregnancy had a 40 per cent lower risk of giving birth to children with childhood autism (classic autism). Use of folic acid supplements midway through pregnancy (week 22) had no effect.

The findings only apply to a lower risk of childhood autism, the most severe form of autism. The results show no reduction in the risk of atypical or unspecific autism. The study also investigated the prevalence of Asperger syndrome, but the number of examined children was too low to give a reliable result.

Food and other supplements did not reduce risk

The researchers found no connection between childhood autism and intake of other supplements during pregnancy. They also found no correlation with maternal intake of folate through food.

“It appears that the reduced risk of childhood autism only reflects folic acid supplements, not food or other supplements, and that the crucial time interval is from four weeks before conception to eight weeks into pregnancy,” says Dr Pål Surén, primary author of the paper and researcher at the Norwegian Institute of Public Health.

Clear results that pave the way for further research

The results show an association between the use of folic acid supplements in the mother during pregnancy and a reduced risk of childhood autism.

“The study does not prove that folic acid supplements can prevent childhood autism. However, the findings are so apparent that they constitute a good argument to further examine possible causal mechanisms. It should also be ascertained whether folic acid is associated with a reduced risk of other brain disorders in children,” says Surén.

Emphasises the importance of folic acid supplements

The results support the Norwegian Directorate of Health’s recommendations for folic acid supplements during pregnancy and emphasise the importance of starting early - preferably before conception.

Method

The ABC Study included participants in the Norwegian Mother and Child Cohort Study (MoBa) who were born in 2002-2008, and included a total of 85,176 children. The mothers had given detailed information about their diet and the use of supplements in early pregnancy. Children with autism diagnoses in MoBa were identified through questionnaires, referrals from parents and health personnel and through links to the Norwegian Patient Register. When the analyses were done, 270 children with autism diagnoses were identified in the study population. Of these children, 114 children had autism, 56 had Asperger syndrome and 100 had atypical or unspecified autism.

The use of folic acid supplements in early pregnancy increased sharply from 2002 to 2008 among women who participated in the Norwegian Mother and Child Cohort Study. 43 per cent of mothers took folic acid supplements in 2002, while the percentage had risen to 85 per cent in 2008. However, many women began later than is desirable; only half of women who took folic acid supplements had begun before conception.

Facts:
Folic acid is a B vitamin that is essential for the construction and repair of DNA molecules, the genetic material which controls all body cells.

Folate is the naturally occurring form of folic acid and is found in leafy vegetables, peas, lentils, beans, eggs, yeast and liver.

For most pregnant women, folic acid supplements are required to reach the recommended levels of folate in the blood.

Some countries add folic acid to flour, so that the entire population receives a supplement, but this is not done in Norway.

Studies from other countries show that many pregnant women consume less dietary folate than is necessary to prevent neural tube defects.

About the study

The ABC study is conducted by the Norwegian Institute of Public Health in collaboration with Columbia University in New York and the National Institute of Neurological Disorders and Stroke (NINDS) in Bethesda, USA. The study received funding from NINDS. In addition, funds for research analysis were provided by the Norwegian Research Council. MoBa is managed by the NIPH.

Intake of folic acid protects the developing brain and spinal cord

The Norwegian Directorate of Health recommends that women who are planning to become pregnant should take folic acid supplements from one month before conception and during the first three months of pregnancy. The recommendation is based on research showing that the use of folic acid supplements in early pregnancy protects the foetus from spina bifida and other neural tube defects.

In recent years, researchers have begun to investigate whether folic acid supplements may also have other beneficial effects on the development of the brain and spinal cord in the foetus. A study from the Norwegian Mother and Child Cohort Study showed that mothers who took folic acid supplements early in pregnancy halved the risk of having children with severe language delay at three years-old. A study of autism spectrum disorders from California found a lower risk of autism among children of expectant mothers who had taken multivitamin supplements containing folic acid.

The authors of the article are: Pål Surén, Christine Roth, Michaeline Bresnahan, Margaretha Haugen, Mady Hornig, Deborah Hirtz, Kari Kveim Lie, W. Ian Lipkin, Per Magnus, Ted Reichborn-Kjennerud, Synnve Schjølberg, George Davey Smith, Anne-Siri Øyen, Ezra Susser and Camilla Stoltenberg.

Reference

Surén P, Roth C, Bresnahan M, et al. Association between maternal use of folic acid supplements and risk of autism in children. JAMA2013, 309 (6): 570-577.

Julie Johansen | EurekAlert!
Further information:
http://www.fhi.no

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>