Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Long-Acting Beta-Agonists Shown to be Most Effective Step-Up Therapy for Children with Poorly Controlled Asthma

03.03.2010
For children whose asthma is not well controlled and on low doses of inhaled corticosteroids, a long-acting beta-agonist (LABA) may be the most effective of three possible step-up treatments. National Jewish clinician-scientists Stanley Szefler, Joseph Spahn, Ronina Covar Gary Larsen and Lynn Taussig, and colleagues in the NIH-funded Childhood Asthma Research and Education Network published their findings March 2, 2010, online in the New England Journal of Medicine.

"This study gives physicians confidence in using long-acting beta-agonists if a patient is not responding to steroid treatment alone," said said Dr. Szefler, Professor of Pediatrics and Pharmacology at National Jewish Health. "It also shows that children respond quite differently to different step-up therapies. Doctors need to monitor their patients closely and consider switching to a higher dose of inhaled corticosteroids or a leukotriene receptor antagonist if the long-acting beta agonist does not improve asthma control."

Approximately 7 million children in the United States have asthma. The prevalence has more than doubled in the past several decades. Asthma in the United States accounts for 500,000 hospitalizations, 10.5 million physician-office visits, and 3,500 deaths as well as millions of missed school days.

Almost all the children responded differently to the three step-up therapies. About 45 percent of the children responded best to the long-acting beta agonist salmeterol, 28 percent responded best to the leukotriene receptor antagonist montelukast, and 27 responded best to doubling the dose of the inhaled corticoteroid fluticasone.

The study, called Best Add on Therapy Giving Effective Responses (BADGER), compared the effectiveness of three different step-up treatments in 182 children ages 6 to 18. Participants had mild to moderate persistent asthma that was not controlled on low-dose inhaled corticosteroids.

Researchers also found that certain patient characteristics indentified which step-up treatment would be most effective. African-Americans were equally likely to respond best to LABA step-up or corticosteroid step-up, but not the montelukast. The addition of LABA step-up therapy was most likely to give the best response to white patients, with inhaled corticosteroid step-up the least favorable. The long-acting beta agonist especially likely to help asthma patients who did not have eczema.

The results of the study were also presented March 2, 2010, at the American Academy of Asthma, Allergy and Immunology Annual Meeting.

National Jewish Health is known worldwide for treatment of patients with respiratory, cardiac, immune and related disorders, and for groundbreaking medical research. Founded in 1899 as a nonprofit hospital, National Jewish remains the only facility in the world dedicated exclusively to these disorders. For 12 consecutive years, U.S. News & World Report has ranked National Jewish the #1 respiratory hospital in the nation.

William Allstetter | EurekAlert!
Further information:
http://www.njhealth.org

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Molecular libraries for organic light-emitting diodes

24.04.2017 | Life Sciences

Research sheds new light on forces that threaten sensitive coastlines

24.04.2017 | Earth Sciences

Making lightweight construction suitable for series production

24.04.2017 | Machine Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>