As the deaths and suffering caused by antibiotic-resistant bacterial infections continue to rise around the world, the Infectious Diseases Society of America (IDSA) is urging a global commitment to develop 10 new antibiotics by 2020, known as the 10 x '20 initiative, to address this public health crisis and safeguard patients' health.
The plea for U.S. and global action comes in a statement—published in the April 15 issue of Clinical Infectious Diseases and available online this week—that outlines the dangers and recommends how to address what the World Health Organization (WHO) has identified as one of the three greatest threats to human health. The IDSA statement is available at www.journals.uchicago.edu/doi/full/10.1086/652237. Recent studies have shown there are few antibiotics in the development pipeline that would offer benefits over existing drugs. The existing drugs we do have available are in danger of becoming ineffective as bacteria increasingly develop resistance.
"Prior generations gave us the gift of antibiotics," said David Gilbert, MD, FIDSA, chair of IDSA's Antimicrobial Availability Task Force, which authored the IDSA statement. "Today, we have a moral obligation to ensure this global treasure is available for our children and future generations."
Solving the antibiotic pipeline problem will require the engagement of global political, scientific, medical, industry and policy leaders to determine the right combination of incentives necessary to drive innovation in this diminishing segment of the pharmaceutical market. The ultimate goal must be the creation of a sustainable research and development enterprise that can deliver new antibiotics on an on-going basis. Resistant organisms will continue to develop in perpetuity, so we must have a plan in place to replenish our arsenal of drugs into the foreseeable future.
"The lack of new antibiotics in the pipeline threatens to leave physicians around the world without the tools they need to effectively treat patients, which could change the practice of medicine as we know it," said IDSA President Richard Whitley, MD, FIDSA. "Advances that we now take for granted, such as surgery, cancer treatment, transplants, and the care of premature babies, could become impossible as our antibiotic options dwindle. If we can initiate a global commitment to achieve this 10 x '20 goal, we will take a giant step toward protecting and ensuring the health of patients worldwide."
Sadly, this commitment will come too late for many patients and families who have already suffered the effects of antibiotic-resistant infections, underscoring the need for quick action to prevent even more suffering. These patients include:
Bryce Smith, who at 14-months-old contracted MRSA pneumonia in 2005 and nearly died. Bryce spent many harrowing weeks in an intensive care unit as doctors struggled to save his life and his parents, Katie and Scott, waited in agony for their son to recover.
For more information on these and other stories about patient's and families' experiences, please see IDSA's website: www.idsociety.org/badbugsnodrugspatientstories.htm.
Antimicrobial resistance has been a primary concern of IDSA's for many years. In 2004, the Society released "Bad Bugs, No Drugs, As Antibiotic Discovery Stagnates, A Public Health Crisis Brews," a report describing the antibiotic resistance crisis and detailing the factors driving drug makers out of the antibiotics market. The report is available at: www.idsociety.org/badbugsnodrugs.html. The Society has also worked with lawmakers to draft the Strategies to Address Antimicrobial Resistance (STAAR) Act, which provides important solutions to contain the spread of antimicrobial-resistant bad bugs. More information about the STAAR Act is available at www.idsociety.org/STAARAct.htm.
The Infectious Diseases Society of America (IDSA) is an organization of physicians, scientists, and other health care professionals dedicated to promoting health through excellence in infectious diseases research, education, patient care, prevention, and public health. The Society, which has more than 9,000 members, was founded in 1963 and is based in Arlington, Va.
John Heys | EurekAlert!
Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering