In a paper published tomorrow in the scientific journal PLoS One, a team of McMaster University researchers report that the health of young adult muscle declines during the pre-diabetic state, which is when blood sugar levels are higher than normal but lower than during Type 2 diabetes. The researchers found that during this period significant impairments occur in the muscle, even though it appears to be functioning normally.
"Based on the way the muscles performed, you would think that they're still healthy," said Thomas Hawke, an associate professor of pathology and molecular medicine of the Michael G. DeGroote School of Medicine at McMaster University. "But the fact is the muscle is not healthy. It's undergone a lot of pathological changes."
Hawke led a team of researchers at McMaster and York universities in using mice to examine how a high-fat diet, leading to obesity, affected the form and function of skeletal muscle. The researchers found the high-fat diet resulted in insulin resistance, large increases in fat mass and weight gain. But it also led to initial adaptations in the muscle.
"What our results tell us is that, initially, skeletal muscle appears to respond positively to the high-fat diet. By changing the size or type of its muscle fibres, the muscle adapts to the high-fat diet by saying 'Let's burn more of this fuel,' " Hawke said.
"But with continued high-fat feeding, we're giving the muscle more fuel than it can handle. So, even though it has made these initial, positive changes, continued high-fat feeding is more than the muscle can cope with. That's when a downward spiral starts."
The researchers also discovered that not all muscles responded in the same way to obesity. Some adapted by changing their fibre type, while others altered the size of their fibres. But, in all cases analyzed, a high-fat diet decreased the ability of skeletal muscle to use fat or glucose as fuel.
When the researchers looked at function, and examined the maximum effort the muscles could generate, they discovered no difference between the high-fat diet group and the control group which was eating a diet significantly lower in fat. However, if the muscles were fatigued and then were required to work, the high-fat diet group didn't recover as quickly as the control group.
"What this suggests is that the muscle is trying to maintain function despite all the negative changes that have resulted," Hawke said. "When we stress the muscle a bit though, such as fatiguing it, there are some hints toward functional impairment, but overall the muscle has coped well, functionally anyways."
The authors concluded that early therapeutic interventions in obese, pre-diabetic youth are needed prior to significant long-term effects on the growth and function of their muscles.
In Canada, 2.4 million people are living with diabetes and up to six million more have pre-diabetes, according to the Canadian Diabetes Association. If left untreated, approximately 25 per cent of people with pre-diabetes will progress to diabetes within three to five years.
Veronica McGuire | EurekAlert!
Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
21.06.2018 | Earth Sciences
21.06.2018 | Life Sciences
21.06.2018 | Earth Sciences