Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High-fat diet impairs muscle health before impacting function

07.10.2009
Skeletal muscle plays a critical role in regulating blood sugar levels in the body. But few studies have comprehensively examined how obesity caused by a high-fat diet affects the health of muscle in adolescents who are pre-diabetic.

In a paper published tomorrow in the scientific journal PLoS One, a team of McMaster University researchers report that the health of young adult muscle declines during the pre-diabetic state, which is when blood sugar levels are higher than normal but lower than during Type 2 diabetes. The researchers found that during this period significant impairments occur in the muscle, even though it appears to be functioning normally.

"Based on the way the muscles performed, you would think that they're still healthy," said Thomas Hawke, an associate professor of pathology and molecular medicine of the Michael G. DeGroote School of Medicine at McMaster University. "But the fact is the muscle is not healthy. It's undergone a lot of pathological changes."

Hawke led a team of researchers at McMaster and York universities in using mice to examine how a high-fat diet, leading to obesity, affected the form and function of skeletal muscle. The researchers found the high-fat diet resulted in insulin resistance, large increases in fat mass and weight gain. But it also led to initial adaptations in the muscle.

"What our results tell us is that, initially, skeletal muscle appears to respond positively to the high-fat diet. By changing the size or type of its muscle fibres, the muscle adapts to the high-fat diet by saying 'Let's burn more of this fuel,' " Hawke said.

"But with continued high-fat feeding, we're giving the muscle more fuel than it can handle. So, even though it has made these initial, positive changes, continued high-fat feeding is more than the muscle can cope with. That's when a downward spiral starts."

The researchers also discovered that not all muscles responded in the same way to obesity. Some adapted by changing their fibre type, while others altered the size of their fibres. But, in all cases analyzed, a high-fat diet decreased the ability of skeletal muscle to use fat or glucose as fuel.

When the researchers looked at function, and examined the maximum effort the muscles could generate, they discovered no difference between the high-fat diet group and the control group which was eating a diet significantly lower in fat. However, if the muscles were fatigued and then were required to work, the high-fat diet group didn't recover as quickly as the control group.

"What this suggests is that the muscle is trying to maintain function despite all the negative changes that have resulted," Hawke said. "When we stress the muscle a bit though, such as fatiguing it, there are some hints toward functional impairment, but overall the muscle has coped well, functionally anyways."

The authors concluded that early therapeutic interventions in obese, pre-diabetic youth are needed prior to significant long-term effects on the growth and function of their muscles.

In Canada, 2.4 million people are living with diabetes and up to six million more have pre-diabetes, according to the Canadian Diabetes Association. If left untreated, approximately 25 per cent of people with pre-diabetes will progress to diabetes within three to five years.

Veronica McGuire | EurekAlert!
Further information:
http://www.mcmaster.ca

Further reports about: McMaster fibre type high-fat diet pre-diabetic skeletal muscle

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>