Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


High-fat diet impairs muscle health before impacting function

Skeletal muscle plays a critical role in regulating blood sugar levels in the body. But few studies have comprehensively examined how obesity caused by a high-fat diet affects the health of muscle in adolescents who are pre-diabetic.

In a paper published tomorrow in the scientific journal PLoS One, a team of McMaster University researchers report that the health of young adult muscle declines during the pre-diabetic state, which is when blood sugar levels are higher than normal but lower than during Type 2 diabetes. The researchers found that during this period significant impairments occur in the muscle, even though it appears to be functioning normally.

"Based on the way the muscles performed, you would think that they're still healthy," said Thomas Hawke, an associate professor of pathology and molecular medicine of the Michael G. DeGroote School of Medicine at McMaster University. "But the fact is the muscle is not healthy. It's undergone a lot of pathological changes."

Hawke led a team of researchers at McMaster and York universities in using mice to examine how a high-fat diet, leading to obesity, affected the form and function of skeletal muscle. The researchers found the high-fat diet resulted in insulin resistance, large increases in fat mass and weight gain. But it also led to initial adaptations in the muscle.

"What our results tell us is that, initially, skeletal muscle appears to respond positively to the high-fat diet. By changing the size or type of its muscle fibres, the muscle adapts to the high-fat diet by saying 'Let's burn more of this fuel,' " Hawke said.

"But with continued high-fat feeding, we're giving the muscle more fuel than it can handle. So, even though it has made these initial, positive changes, continued high-fat feeding is more than the muscle can cope with. That's when a downward spiral starts."

The researchers also discovered that not all muscles responded in the same way to obesity. Some adapted by changing their fibre type, while others altered the size of their fibres. But, in all cases analyzed, a high-fat diet decreased the ability of skeletal muscle to use fat or glucose as fuel.

When the researchers looked at function, and examined the maximum effort the muscles could generate, they discovered no difference between the high-fat diet group and the control group which was eating a diet significantly lower in fat. However, if the muscles were fatigued and then were required to work, the high-fat diet group didn't recover as quickly as the control group.

"What this suggests is that the muscle is trying to maintain function despite all the negative changes that have resulted," Hawke said. "When we stress the muscle a bit though, such as fatiguing it, there are some hints toward functional impairment, but overall the muscle has coped well, functionally anyways."

The authors concluded that early therapeutic interventions in obese, pre-diabetic youth are needed prior to significant long-term effects on the growth and function of their muscles.

In Canada, 2.4 million people are living with diabetes and up to six million more have pre-diabetes, according to the Canadian Diabetes Association. If left untreated, approximately 25 per cent of people with pre-diabetes will progress to diabetes within three to five years.

Veronica McGuire | EurekAlert!
Further information:

Further reports about: McMaster fibre type high-fat diet pre-diabetic skeletal muscle

More articles from Health and Medicine:

nachricht Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital

nachricht Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel light sources made of 2D materials

Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.

So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Prototype device for measuring graphene-based electromagnetic radiation created

28.10.2016 | Power and Electrical Engineering

Gamma ray camera offers new view on ultra-high energy electrons in plasma

28.10.2016 | Physics and Astronomy

When fat cells change their colour

28.10.2016 | Life Sciences

More VideoLinks >>>