Daily intake of a lactic acid bacteria, which has been given the name Lactobacillus plantarum HEAL19, appears to be able to prevent obesity and reduce the body’s low-level inflammation.
“Rats who were given this specific lactic acid bacterium from their time in the uterus up to adult age put on significantly less weight than other rats. Both groups ate the same amount of high-energy food”, explains Caroline Karlsson, a researcher in food hygiene at Lund University.
Ms Karlsson also observed that the rats which were given lactobacilli had a richer and better composition of the bacteria which occur naturally in the intestines. A healthy gut flora should contain a large proportion of ‘good bacteria’, such as lactic acid bacteria, in order to keep the inflammation-causing bacteria in check.
A third group of rats were given the inflammation-causing Escherichia coli bacteria in their drinking water, in addition to the same high-energy food as the other rats. The E. coli supplement led to changes in gut flora and increased body fat. The findings were published recently in the British Journal of Nutrition and form part of the doctoral thesis that Caroline Karlsson recently presented.
In another study, Caroline Karlsson has studied the first faeces of 79 children born vaginally. A foetus lives in a sterile environment and therefore has no micro-organisms in its intestines, but during birth the baby swallows the lactobacilli that are naturally present in its mother’s vagina.
“It had not previously been shown that all newborn babies born vaginally have lactobacilli in their gut flora as early as two days after birth. Thanks to the application of a gene-based technique, we have been able to show in our study that this is in fact the case”, says Caroline Karlsson, who also found that babies with high birth weight had more inflammation-causing bacteria, such as E. coli, in their intestines than babies of normal weight.
A healthy gut flora at an early stage appears to play a part in children’s wellbeing later in life. This is a conclusion in a further study, where Caroline Karlsson showed that children with allergic eczema at the age of 18 months had a lower diversity in the gut flora when they were just one week old compared with the children who did not develop allergic eczema.
In the aforementioned study on rats, it emerged that the mother’s diet and bacteria consumption affect the development and health of her young.
“A number of female rats were given food with high energy content during pregnancy and while they were suckling their young. We saw that, at two weeks of age, the young whose mothers were given high-energy food had higher body weight and more fat in their bodies, as well as higher levels of inflammation, than young whose mothers were given a more balanced diet”, explains Caroline Karlsson.
The research was financed by Formas.
Caroline Karlsson defended her thesis, The Gut Bacterial Flora - Focus on Early Life and Physiological Traits on Friday, 6 May at Kemicentrum, Lund University.About probiotics
“Certain foods, for example olives, yoghurt and cheese, naturally contain lactobacilli – the type of bacteria most often used as probiotics. Such bacteria were more common in the past, when food was fermented to extend its shelf life. Today, when fridges and heat treatment of food kill off both harmful and beneficial bacteria, we ingest too little of the “friendly bacteria”, explains Göran Molin.
The lactic acid bacteria Lactobacillus plantarum HEAL19 has been isolated from healthy intestinal mucous membranes in humans. It is patented but is not used as an additive in any food products. Examples of probiotic bacteria used by the food industry are: L. plantarum 299v, L. plantarum HEAL9, L. paracasei 8700:2, L. paracasei F19. These all belong to the same bacterial genus.
For more information, please contact Professor Siv Ahrné, Applied Nutrition and Food Chemistry, +46 46 222 83 27, +46 703 484 516, Siv.Ahrne@appliednutrition.lth.se, or Professor Göran Molin, Applied Nutrition and Food Chemistry, +46 46 222 83 27 (same telephone number as Siv Ahrné), Goran.Molin@appliednutrition.lth.se. Caroline Karlsson can be contacted on firstname.lastname@example.org, +46 46 222 83 26.
High-definition photographs of Caroline Karlsson are available in the Lund University image bank, http://bildweb.srv.lu.se/. Enter “Caroline Karlsson” in the search field.
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research