Publishing in The FASEB Journal, the authors describe how in laboratory tests, they compared the protection offered against either UVA radiation or free radical stress by several antioxidants, some of which are found in foods or cosmetics.
While UVB radiation easily causes sunburn, UVA radiation penetrates deeper, damaging our DNA by generating free radicals which degrades the collagen that gives skin its elastic quality.
The Newcastle team found that the most potent anti-oxidants were those that targeted the batteries of the skin cells, known as the mitochondria. They compared these mitochondrial-targeted anti-oxidants to other non-specific antioxidants such as resveratrol, found in red wine, and curcumin found in curries, that target the entire cell. They found that the most potent mitochondrial targeted anti-oxidant was Tiron which provided 100%, protection of the skin cell against UVA sun damage and the release of damaging enzymes causing stress-induced damage.
Author, Mark Birch-Machin, Professor of Molecular Dermatology at Newcastle University said: “To discover that Tiron offers complete protection against UVA damage is exciting and promising, however, it is early days as Tiron is not a naturally occurring compound and has not yet been tested for toxicity in humans although there have been a few studies on rats.”
Of the work which was funded by BBSRC and Unilever, co-author at Newcastle University Dr Anne Oyewole said: “This finding on Tiron provides us with a platform to study an antioxidant - preferably a naturally occurring compound with a similar structure which could then be safely added to food or cosmetics.”
Our skin ages due to the constant exposure to sunlight as ultraviolet radiation from the sun penetrates cells and increases the number of damaging free radicals, especially the reactive oxygen species. Too many reactive oxygen species can be harmful because they can damage the DNA within our cells.
Over time, this can lead to the accumulation of mutations which speed up ageing and destroy the skin’s supportive fibres, collagen and elastin, causing wrinkles. Recent studies strongly suggest the damage caused by reactive oxygen species may also initiate and exacerbate the development of skin cancers.
Antioxidants in our diets from green tea, resveratrol which is found in red wine, turmeric which is used in curries and lycopene found in tomatoes, as well as some components in cosmetic creams, are known to neutralise this damage within the cells. They can slow down the damage and the rate of ageing and potentially lower the rate of other sun-induced skin lesions.
The method developed offers the first test which enables the comparison of different antioxidants for their potency in a skin cell based system.
Skin cells treated with a panel of antioxidants were exposed to a physiological dose of ultraviolet A radiation – that is, the same dose that our skin would normally be exposed to on a warm summer’s day. The DNA within the skin cells was then copied using a polymerase chain reaction machine, in order to assess the amount of DNA damage present.
Using this method, Tiron which has the chemical composition 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt monohydrate was revealed to provide 100% protection against mitochondrial DNA damage.
Resveratrol, the antioxidant found in red wine, was found to protect against 22% of both the ultraviolet A radiation and stress-induced damage. NAC, a frequently used laboratory-based anti-oxidant, offered 20% protection against oxidative stress and 8% against UVA and curcumin offered 16% protection against oxidative stress and 8% against UVA.
In comparison Tiron offered 100% protection against UVA radiation and 100% protection against oxidative stress.
The team intends to take the work forward by further understanding the mechanism of how Tiron works, developing a compound similar to Tiron and testing for toxicity in humans. They say it will be several years before it is ready for use as a skin product or supplement.
Reference: Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide. Anne O. Oyewole, Marie-Claire Wilmot, Mark Fowler, and Mark A. Birch-Machin. The FASEB Journal. doi: 10.1096/fj.13-237008
published on: 10th January 2014
Karen Bidewell | EurekAlert!
Fiber optic biosensor-integrated microfluidic chip to detect glucose levels
29.04.2016 | The Optical Society
Got good fat?
27.04.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...
As one of the leading R&D partners in the development of surface technologies and organic electronics, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP will be exhibiting its recent achievements in vacuum coating of ultra-thin glass at SVC TechCon 2016 (Booth 846), taking place in Indianapolis / USA from May 9 – 13.
Fraunhofer FEP is an experienced partner for technological developments, known for testing the limits of new materials and for optimization of those materials...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
29.04.2016 | Physics and Astronomy
29.04.2016 | Health and Medicine
29.04.2016 | Life Sciences