Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Failed autoimmune suppression mechanism new clue to lupus

04.02.2011
Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.

Correcting the defect “may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease,” the researchers state in their research paper, published in the Proceedings of the National Academy of Sciences.

The research team was led by Harvey Cantor, M.D., chair of the department of cancer immunology and AIDS at Dana-Farber, in collaboration with the laboratory of Jackson Professor Derry Roopenian, Ph.D.

Autoimmune diseases develop when the immune system, which is supposed to identify and vanquish potentially dangerous infectious agents, instead attacks the individual's own body. Most autoimmune diseases strike specific organs, such as the pancreas in type 1 diabetes. Lupus, however, is a systemic disease in which abnormal antibodies are produced throughout the body, inflaming a variety of tissues and organs, including the skin, heart, lungs, kidneys and brain.

Follicular T helper (TFH) cells fuel B cells to produce antibodies, which can be useful in fighting infections. But in lupus, TFH fuel B cells that produce dangerous antibodies that attack normal tissues (autoantibodies). CD8+ T cells (“killer T cells”), on the other hand, normally attack and destroy only infected cells. Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus. These so-called CD8+ T regulatory, or Treg, cells are specially equipped to destoy TFH cells, and by doing so, prevent lupus from developing.

Using a mouse model for systemic lupus erythematosus in humans that was originally discovered at 30 years ago by Edwin Murphy at The Jackson Laboratory, the Dana-Farber researchers, working with Roopenian’s laboratory, found defects in CD8+ Treg activity.

The new paper, Roopenian explains, is the first to demonstrate the potential breakdown of this suppression mechanism in lupus. “Overcoming this defect,” he says, “offers a potential approach prevent lupus.”

The Jackson Laboratory is a nonprofit biomedical research institution based in Bar Harbor, Maine. Its mission is to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and education for the global biomedical community.

Kim et al.: Surface phenotype and function of CD8+ T regulatory cells: Defective Ly49+ CD8+ T regulatory cell activity is a hallmark of B6-Yaa autoimmunity. Proceedings of the National Academy of Sciences, doi/10.1073/pnas.1018974108

Contact(s):
Joyce Peterson, 207-288-6058, The Jackson Laboratory

Joyce Peterson | EurekAlert!
Further information:
http://www.jax.org

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>