Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early signs of heart disease in preadolescent children with type 1 diabetes

15.02.2011
Cardiovascular disease is the leading cause of death in patients with diabetes. Patients with type 1diabetes have a 200 percent to 400 percent greater chance of developing cardiovascular disease than those without diabetes.

Medical College of Wisconsin researchers at Children's Hospital of Wisconsin discovered the early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with diabetes.

Those findings are published in the February 2, 2011 online version of Diabetes Care and will be in the March 2011 issue of Diabetes Care.

Led by Dr. Ramin Alemzadeh, professor of pediatrics at the college and pediatric endocrinologist at Children's Hospital of Wisconsin, and Senior Clinician Scientist at Children's Hospital's Max McGee Juvenile Diabetes Research Center, the researchers studied 21 preadolescent children (avg. age 8.5 years) with type 1 diabetes, and compared that group to 15 healthy siblings. Investigators looked at flow-mediated dilatation (FMD), a gauge of the health of a major blood vessel of the upper arm artery, in both groups. FMD percentage (FMD%,) is a way to measure any stiffening of the blood vessels; stiffening blood vessels is an early precursor of cardiovascular disease.

Children who had high blood pressure, family history of high cholesterol or premature cardiovascular disease from other causes were excluded. Blood samples were collected from all participants to monitor cholesterol and sugar levels.

When tested, the blood vessels of children with type 1 diabetes had a lower FMD% change, which means their blood vessels were less expandable than the control group suggesting that higher circulating glucose results in increased rigidity of blood vessels independent of serum cholesterol levels. The patients with diabetes also had vascular inflammation, which is a known harbinger of future cardiovascular risk. Long-term studies are needed to evaluate the progression of those vascular changes through puberty and beyond.

The published paper, "Impaired Endothelial Function in Preadolescent Children with Type 1 Diabetes," was co-authored by Dr. Ghufran S. Babar, M.D., Children's Mercy Hospital, Kansas City, Missouri; Dr. Hanaa Zidan, M.D., Children's Hospital of Michigan, Detroit. .; Dr. Michael E. Widlansky, M.D., Medical College of Wisconsin.; Dr. Emon Das, M.D., Medical College of Wisconsin, Dr. Raymond G. Hoffman, PhD, Children's Research Institute of Children's Hospital of Wisconsin; and Dr. Marwan Daoud, Ph.D., Wayne State School of Medicine, Detroit.

About The Medical College of Wisconsin:

The Medical College of Wisconsin is the state's only private medical school and health sciences graduate school. Founded in 1893, it is dedicated to leadership and excellence in education, patient care, research and service. Approximately 1,200 students are enrolled in the Medical College's medical school and graduate school programs A major national research center, it is the largest research institution in the Milwaukee metro area and second largest in Wisconsin. In FY 2009 -10, faculty received approximately $161 million in external support for research, teaching, training and related purposes, of which $148 million is for research. This total includes highly competitive research and training awards from the National Institutes of Health (NIH). Annually, College faculty direct or collaborate on more than 2,000 research studies, including clinical trials. Additionally, more than 1,200 faculty physicians provide care in virtually every specialty of medicine to approximately 390,000 patients annually.

Maureen Mack | EurekAlert!
Further information:
http://www.mcw.edu

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>