The article is being published in the respected scientific journal, Proceedings of the National Academy of Sciences (PNAS). The study includes 165 children with neuroblastoma, most of whom developed the disease before the age of five. These children have been monitored for over 20 years by two research teams led by professors Tommy Martinsson, of the Sahlgrenska Academy, and Per Kogner of Karolinska Institutet.
Neuroblastoma is a nerve cell cancer that has defects in certain chromosomes. If the tumour has a characteristic defect on chromosome 11, it is very aggressive and difficult to cure.
"We found that the children who develop this type of neuroblastoma are twice as old at the onset of the disease as children who develop other types of neuroblastoma. This type progresses more slowly and is more difficult to treat," says Helena Carén, a researcher at the Department of Clinical Genetics at the Sahlgrenska Academy.
By using the latest genetic techniques, the researchers have succeeded in analysing the DNA of tumour cells and identifying chromosomal defects, enabling the identification of sub-groups of the most aggressive neuroblastomas. The next step is to identify their weak points genetically in order to develop better treatment.
"We call this personalized medicine, because the treatment is based on the genetic profile of the patient, or in this case, of the tumour cells," says Tommy Martinsson, professor of genetics at the Department of Clinical Genetics at the Sahlgrenska Academy.
Per Kogner, professor of paediatric oncology at Karolinska Institutet, reiterates that their discovery will now allow a variety of tailor-made treatments to be developed, saving the lives of more children.
The study was carried out with the support of the Swedish Childhood Cancer Foundation and the Swedish Cancer Society.ABOUT NEUROBLASTOMA
For further information, please contact:
Helena Carén, doctor of medical science at the Sahlgrenska Academy, telephone +46 (0)31-343 41 57, +46 (0)706- 82 32 62, email@example.com
Tommy Martinsson, professor and chief geneticist (principal study investigator) at the Sahlgrenska Academy, tel +46 (0)31- 343 48 03, tel +46 (0)739-81 71 12 firstname.lastname@example.org
Per Kogner, professor and paediatric oncologist at the Astrid Lindgren Children's Hospital and researcher at Karolinska Institutet, +46 (0)8-5177 35 34, +46 (0)70-571 39 07, email@example.com
Helena Aaberg | idw
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
21.03.2018 | Life Sciences
21.03.2018 | Trade Fair News
20.03.2018 | Physics and Astronomy