The study, published today in Nature Communications, explains how this tiny 'railway' system is a key target for cancer drugs and, as such, how this new discovery reveals how better drugs might be made. The tracks of this so called 'railway' are tiny tubes, called microtubules, 1000 times thinner than a human hair.
Researchers at Warwick Medical School have found that the minuscule tracks of a cellular railway system have a line of weakness, which tends to crack and cause the tracks to dissolve. Cancer drugs already target these microscopic railway tracks, which are called microtubules and are a thousand times thinner than a human hair.
Credit: Prof. Robert Cross, Warwick Medical School
The research shows that a narrow seam that runs along the length of the microtubules is the weakest point. If the seam cracks and splits, the microtubule dissolves.
It has been known for some time that microtubules have a single seam that zips the structure together along its length, but the function of this seam has evaded scientists until now. By building microtubules with extra seams in the laboratory, and examining their stability using video microscopes, the researchers found that the more seams the microtubule has, the more unstable it becomes.
The new work dramatically alters thinking on how the microtubule system works and the search is now on for factors inside the cell that influence the stability of microtubule seams.
Microtubules are a validated target for cancer therapy drugs. For example Taxol™, used in breast cancer therapy, binds to microtubules and stops the microtubule from dissolving. This means the microtubule tracks cannot remodel themselves prior to cell division, which in turn stops the cells dividing, thus arresting the growth of cells including those forming cancerous tumours.
Professor Robert Cross, head of the research team at Warwick Medical School, explained, "It is clear that any new drugs aiming to stabilize or destabilize microtubules must target the microtubule seam. We expect this to lead us to a better understanding of the way microtubules are regulated in cells and why this sometimes goes wrong, such as in development of cancer."
"Our findings help us to understand how some existing cancer treatment drugs actually work and this in turn should lead to development of new generations of better and more effective anti-microtubule drugs."
The research was funded by the Association for International Cancer Research (AICR) and Marie Curie Cancer Care.
Luke Harrison | EurekAlert!
Consensus in the Fight Against Colorectal Cancer
31.05.2016 | Universität Bern
Nanotubes are beacons in cancer-imaging technique
23.05.2016 | Rice University
Physicists of the Laboratory for Attosecond Physics at the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität Munich in collaboration with scientists from the Friedrich-Alexander-Universität Erlangen-Nürnberg have observed a light-matter phenomenon in nano-optics, which lasts only attoseconds.
The interaction between light and matter is of key importance in nature, the most prominent example being photosynthesis. Light-matter interactions have also...
A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.
The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
31.05.2016 | Power and Electrical Engineering
31.05.2016 | Life Sciences
31.05.2016 | Information Technology