Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Consensus in the Fight Against Colorectal Cancer

31.05.2016

In colorectal cancer, the presence of invasive tumor cells at the advancing edge of the tumor can provide valuable information on prognosis. Initiated by the Colorectal Cancer Research Group at the Institute of Pathology, University of Bern, a consensus conference was held to determine how this phenomenon should best be put into practice. Together with colleagues from eleven countries, an internationally standardized scoring method was established.

With over a million new cases per year, colorectal cancer is one of the most commonly diagnosed cancers across the globe. Despite recent advances in medical research, the prognosis of patients who present with advanced tumors remains relatively poor.


Tumor buds (marked by the black arrows) are single cells or small clusters of tumor cells which detach from the main tumor body and invade surrounding tissue.

Picture: University of Berne, Institute of Pathology

The treatment of colorectal cancer requires an interdisciplinary approach. After surgery is performed to remove the cancer with part of the colon, the specimen is then examined by a physician with specialist training pathology who is responsible for confirming the diagnosis and determining tumor stage.

Additionally, in order to evaluate the biological behavior of an individual tumor the pathologist can also examine certain biomarkers, either microscopically or by additional molecular analysis. The information from such biomarkers may be of prognostic value, or predict response to a given therapy, so that treatment strategies can be tailored to individual patients.

Biomarkers for more precise prognosis

The phenomenon of ‘tumor budding’ has received increasing attention in the medical literature as an indicator of aggressiveness in colorectal cancer. Single cancer cells or small clusters of cancer cells gain the ability to detach from the main tumor body and increase the risk of colonization of other organs via lymphatic and blood vessels, ultimately leading to fatality.

However, until now, there has been no established and internationally recognized system to assess tumor budding in order for it to be used to influence clinical management decisions that directly affect patient care.

Bernese efforts to achieve consensus

At the end of April 2016, an international tumor budding consensus conference (ITBCC) initiated by the Colorectal Cancer Research Group was held in order to develop an internationally standardized method of assessing tumor buds. The method is cheap, can be performed anywhere and can replace in some circumstances expensive molecular testing.

This was a revolutionary step in improving biomarker assessment in colorectal cancer. The next step is to implement tumor budding as a prognostic indicator in national guidelines as well as colorectal cancer reporting recommendations of the World Health Organization (WHO), the UICC (Union Intérnationale Contre le Cancer) and the AJCC (American Joint Committee on Cancer).

«Reporting of tumor budding by pathologists worldwide will help serve as the basis for future clinical studies geared at the development of novel therapies targeted at tumor buds», says Alessandro Lugli, Head of the Division of Clinical Pathology at the Institute of Pathology.

Weitere Informationen:

http://www.unibe.ch/news/media_news/media_relations_e/media_releases/2016_e/medi...
http://www.pathology.unibe.ch/index_eng.html

Nathalie Matter | Universität Bern

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>