Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Community-acquired pneumonia in influenza season: There's a bad strain on the rise

09.11.2009
ROME - Infections due to methicillin-resistant Staphylococcus aureus (MRSA) strains are no longer confined to hospitals but occur more and more in communities.

Two articles in the European Respiratory Journal's November issue are dedicated to this dangerous and versatile microorganism.

For many years, MRSA infections were associated with hospitalised, high-risk patients.

Not only has the infection pattern recently shifted from hospital-acquired (nosocomial) to community-onset infections, but new strains have emerged, affecting young individuals, who don't have any risk factors. It seems that everything we know about these bacteria is becoming obsolete, to such an extent that a group of Italian researchers are now asking: "What is MRSA?"

This question (and the answer) is dealt with by Dr. Annalisa Pantosi from the Istituto Superiore di Sanita in Rome, Italy, and her colleagues in a current ERJ article.

Besides the hospital setting, every doctor associates MRSA with being a multiresistant bacterial pathogen - after all, even its name is based on its antibiotic sensitivity (or lack thereof). Able to destroy penicillin by producing an enzyme called penicillinase, MRSA earned its name because of a sophisticated genetic adaptation that enables it to bypass the effects of Methicillin, which blocks construction and maintenance of the bacterial cell wall. As a consequence, MRSA is resistant not only to methicillin but also to all beta-lactam antibiotics, including cephalosporins and carbapanems.

Staphylococcal infections are a concern not only from the respiratory point of view - the organ system commonly involved is the skin, with furunculosis and impetigo being frequent manifestations. In addition, they can result in serious bloodstream infections (sepsis) and can infect prosthetic implants.

The "new generation" of MRSA strains commonly causes skin and soft- tissue infections. However, even if cases of community-acquired pneumonia due to MRSA are still rare, when respiratory infections occur, they are severe and carry a high mortality.

"The estimated incidence is 0.51-0.64 cases per 100.000 people" report Dr. Konstantinos Vardakas and his colleagues from the Alfa Institute of Biomedical Sciences in Athens, Greece.

In Europe, the prevalence of infections due to this community-acquired MRSA (CA-MRSA) strain is lower than in the US. Nevertheless, physicians need to be aware of any infection that might be caused by a potentially multiple-drug resistant strain.

Moreover, MRSA-pneumonia in the community setting is often preceded by influenza or an influenza-like illness, a phenomenon that may well become relevant in the upcoming influenza season and amid the ongoing pandemic of H1N1 influenza, writes Dr. Alexandra Nakou in an accompanying editorial.

Dr. Nakou adds: "Although community-acquired MRSA is sensitive to several antibiotics such as clindamycin, trimethoprim-sulphamethoxazole and tetracyclines, the optimal treatment is not yet established. The current guidelines recommend the use of vancomycin or linezolid."

"MRSA should be part of the differential diagnosis of severe pneumonia during the influenza season, especially in patients with evidence of necrosis and in those with a history of MRSA infection".

Dr. Anka Stegmeier-Petroianu | idw
Further information:
http://www.ersnet.org

More articles from Health and Medicine:

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>