For this, it is essential to provide tests that allow early detection of cancer without the need of a tissue sample, and thus drastically improve the prognosis of the patients and their chance of a cure. Currently established cancer diagnostics either identify the disease too late or are unreliable, resulting in false positives, which can unsettle patients.
For instance, measuring PSA-levels for prostate cancer detection and mammographies for breast cancer prevention can provide false positive results without acute malignancies being found. Additionally, currently no blood test is available for oral cancer.
A novel blood test for the detection of cancer has been clinically assessed in a collaborative study between the university hospital Tuebingen, the German Cancer Research Center in Heidelberg, and the Clemenshospital of the university hospital muenster. This blood test utilizes the immune system; specifically the activity of macrophages, a type of white blood cell that scavenges tumor cells.
Using laser-based detection methods of tumor material within these scavenger cells, also known as EDIM (epitope detection in monocytes)-technology, it is now possible to discover the presence of tumor cells in small blood samples. This has allowed the early detection of oral, prostate, and breast cancer as well as relapses in patients by the EDIM-technology. Thus, this technology is also suitable for monitoring therapeutic efficacy. The results of this study represent an important hallmark in cancer detection, driven by the improved accuracy of the EDIM-blood test compared to previously established test methodologies.
publicationA biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells
Dr. Ellen Katz | idw
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
A new approach to high insulin levels
18.09.2017 | Schweizerischer Nationalfonds SNF
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
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