Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antibiotic may reduce stroke risk and injury in diabetics

25.08.2010
A daily dose of an old antibiotic may help diabetics avoid a stroke or at least minimize its damage, Medical College of Georgia researchers report.

Minocycline, a drug already under study at MCG for stroke treatment, may help diabetics reduce remodeling of blood vessels in the brain that increases their stroke risk and help stop bleeding that often follows a stroke, said Dr. Adviye Ergul, physiologist in the MCG Schools of Medicine and Graduate Studies.

"We know that diabetes is bad and that diabetics have more strokes and that when they have a stroke they do more poorly," said Ergul, corresponding author on the study published in the Journal of Cerebral Blood Flow and Metabolism. Nearly 70 percent of the estimated 24 million Americans with diabetes list a major vascular event such as a stroke or heart attack as a cause of death, according to the American Diabetes Association.

To figure out why, the researchers focused on the blood vessels of diabetic rats, finding that even moderately elevated blood glucose levels can result in thicker, twisted blood vessels that tend to leak, resulting in the bleeding that can follow a stroke. Clot-based strokes are the most common type while hemorrhagic strokes tend to be most lethal. But diabetics are at risk for a sort of combination in which a clot causes the stroke and leaking from the blood vessels follows – called hemorrhagic transformation – a scenario that can dramatically worsen the stroke's effect, Ergul said.

Much of the bad vascular remodeling that occurs in diabetes results from elevated glucose activating matrix metalloproteinases or MMPs. "They break down things and allow for cells to move so blood vessels change shape," Ergul said. They also destroy the basement membrane of blood vessels, allowing the destructive bleeding that often follows a diabetic stroke. On the good side, MMPs help clean up damage to enable repair and recovery.

One way minocycline works is by blocking MMPs. Less directly, diabetes drugs like metformin, used to lower blood sugar, also reduce MMP levels.

Another MCG research team, led by Dr. David Hess, stroke specialist and chairman of the Department of Neurology, is showing that minocycline given alone or with tPA, the clot dissolver that is the only FDA-approved stroke treatment, can also work after a stroke to help minimize damage. One great synergy about the pair is that tPA increases bleeding risk and minocycline decreases it.

That could particularly benefit diabetics who already are at increased risk for bleeding, particularly when oxygen is restored to that area of the brain. This damage – called a reperfusion injury – is a primary reason that a diabetic stroke may look small on a magnetic resonance image but can have a devastating, effect, Ergul also has found.

Some of her next studies will include giving both tPA and minocycline to diabetic rats to study bleeding and the impact of the two drugs on blood vessels, particularly the tiny ones that are tightly connected to brain cells.

The research was funded by the National Institutes of Health, the American Heart Association and the Department of Veterans Affairs.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>