Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A holistic approach catches eye disease early

11.10.2013
An automated assessment of multiple datasets using artificial intelligence accurately diagnoses a common cause of blindness

Pathological myopia is a condition characterized by severe, progressive nearsightedness caused by the protrusion of pigmented tissue from the back of the eye.

The disease is one of the leading causes of blindness worldwide and the leading cause in Asian countries. Early diagnosis is essential for preventing permanent loss of vision but heavily relies on manual screening and involves a complete eye exam, which can take up to an hour.

Zhuo Zhang of the A*STAR Institute for Infocomm Research in Singapore and her colleagues have now developed an automated, computer-assisted informatics method that uses artificial intelligence to diagnose the condition accurately1.

In earlier work, Zhang and her colleagues developed an algorithm that could extract information about tissue texture from biomedical images of the back of the eye, or fundus, and use it to detect pathological myopia with an accuracy of 87.5%. They then showed that combining the images with demographic data such as age, sex and ethnicity, improved the accuracy further.

The latest automated method — Pathological Myopia diagnosis through Biomedical and Image Informatics (PM-BMII) — takes the process one step further; it uses an artificial intelligence approach known as multiple kernel learning to fuse the demographic data and clinical fundus images with genomic information and then analyze the combined datasets (see image).

Zhang and her colleagues tested the method on data collected from 2,258 patients, 58 of whom had already been diagnosed with pathological myopia. They found that the method could detect the condition with a high degree of accuracy and that the combination of all three datasets was more accurate than any one alone or any two combined.

Combining the three datasets probably produced the best results because each set contains different information that complements the other sets, therefore providing a holistic assessment of the disease.

The researchers suggest that the method could also be applied to the detection of other eye diseases, “including age-related macular degeneration and glaucoma. These diseases have common characteristics,” says Zhang. “They result from both environmental and genetic risk factors, and can be observed from fundus images.”

Zhang adds that it is still unclear whether adding additional types of data to the analyses would improve the accuracy of the diagnoses. “More types of data may introduce complexity into the computational model, so we cannot draw the conclusion that accuracy would be improved without further investigation.”

The A*STAR-affiliated researchers contributing to this research are from the Institute for Infocomm Research

Journal information

Zhang, Z., Xu, Y., Liu, J., Wong, D. W. K., Kwoh, C. K. et al. Automatic diagnosis of pathological myopia from heterogeneous biomedical data. PLoS ONE 8, e65736 (2013).

A*STAR Research | Research asia research news
Further information:
http://www.a-star.edu.sg
http://www.researchsea.com

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>