To help surgeons in such high-pressure situations, researchers from Prof. Adam Wax's team at Duke University's Fitzpatrick Institute for Photonics and Biomedical Engineering Department have proposed a way to harness the unique optical properties of gold nanoparticles to clearly distinguish a brain tumor from the healthy, and vital, tissue that surrounds it. The team will present their findings at the Optical Society's (OSA) Annual Meeting, Frontiers in Optics (FiO) 2011 (http://www.frontiersinoptics.com/), taking place in San Jose, Calif. next week.
Current techniques for outlining brain tumors vary, but all have limitations, such as the inability to perform real-time imaging without big, expensive equipment, or the toxicity and limited lifespan of certain labeling agents. Gold nanoparticles—which are so small that 500 of them end-to-end could fit across a human hair—might provide a better way to flag tumorous tissue, since they are non-toxic and relatively inexpensive to manufacture.
The Duke researchers synthesized gold, rod-shaped nanoparticles with varying length-to-width ratios. The different-sized particles displayed different optical properties, so by controlling the nanorods' growth the team could "tune" the particles to scatter a specific frequency of light. The researchers next joined the tuned particles to antibodies that bind to growth factor receptor proteins found in unusually high concentrations on the outside of cancer cells. When the antibodies latched on to cancer cells, the gold nanoparticles marked their presence.
The team tested the method by bathing slices of tumor-containing mouse brain in a solution of gold nanoparticles merged with antibodies. Shining the tuned frequency of light on the sample revealed bright points where the tumors lurked. The tunability of the gold nanoparticles is important, says team member Kevin Seekell, because it allows researchers to choose from a window of light frequencies that are not readily absorbed by biological tissue. It might also allow researchers to attach differently tuned nanoparticles to different antibodies, providing a way to diagnose different types of tumors based the specific surface proteins the cancer cells display. Future work by the team will also focus on developing a surgical probe that can image gold nanoparticles in a living brain, Seekell says.
FiO presentation FWL4, "Controlled Synthesis of Gold Nanorods and Application to Brain Tumor Delineation," by Kevin Seekell et al. is at 11:45 a.m. on Wednesday, Oct. 19.
EDITOR'S NOTE: High-resolution images are available upon request. Contact Angela Stark, email@example.com.
About the Meeting
Frontiers in Optics 2011 is OSA's 95th Annual Meeting and is being held together with Laser Science XXVII, the annual meeting of the American Physical Society (APS) Division of Laser Science (DLS). The two meetings unite the OSA and APS communities for five days of quality, cutting-edge presentations, fascinating invited speakers and a variety of special events spanning a broad range of topics in physics, biology and chemistry. FiO 2011 will also offer a number of Short Courses designed to increase participants' knowledge of a specific subject while offering the experience of insightful teachers. An exhibit floor featuring leading optics companies will further enhance the meeting.
Useful Links:•Meeting home page (http://www.frontiersinoptics.com/)
•Searchable abstracts (http://fio-ls2011.abstractcentral.com/login)
PRESS REGISTRATION: A Press Room for credentialed press and analysts will be located in the Fairmont San Jose Hotel, Sunday through Thursday, Oct. 16-20. Those interested in obtaining a press badge for FiO should contact OSA's Angela Stark at +1 202.416.1443 or firstname.lastname@example.org.
Uniting more than 130,000 professionals from 175 countries, the Optical Society (OSA) brings together the global optics community through its programs and initiatives. Since 1916 OSA has worked to advance the common interests of the field, providing educational resources to the scientists, engineers and business leaders who work in the field by promoting the science of light and the advanced technologies made possible by optics and photonics. OSA publications, events, technical groups and programs foster optics knowledge and scientific collaboration among all those with an interest in optics and photonics. For more information, visit www.osa.org.
Angela Stark | EurekAlert!
XXL computed tomography: a new dimension in X-ray analysis
17.05.2018 | Fraunhofer-Gesellschaft
Why we need erasable MRI scans
26.04.2018 | California Institute of Technology
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology