Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRI pinpoints region of brain injury in some concussion patients

15.04.2014

Researchers using information provided by a magnetic resonance imaging (MRI) technique have identified regional white matter damage in the brains of people who experience chronic dizziness and other symptoms after concussion.

The findings suggest that information provided by MRI can speed the onset of effective treatments for concussion patients. The results of this research are published online in the journal Radiology.

Concussions, also known as mild traumatic brain injury (mTBI), affect between 1.8 and 3.8 million individuals in the United States annually.

One of the most common and debilitating effects of concussion is vestibulopathy, a condition characterized by dizziness, imbalance and visual problems. Vestibulopathy impairs activities of daily living and puts patients at increased risk for a second injury. Up until now, no specific brain regions have been linked to the prognosis of patients with vestibulopathy.

For the study, the researchers retrospectively reviewed imaging data from 30 mTBI patients with vestibular symptoms and 25 with ocular convergence insufficiency, a condition that occurs when the eyes don't turn inward properly when focusing on a nearby object. Controls consisted of 39 mTBI patients without vestibular abnormalities and 17 with normal ocular convergence. The imaging data was acquired using an MRI technique called diffusion tensor imaging (DTI), which produces a fractional anisotropy (FA) value that can be used to determine damage to the brain's signal-transmitting white matter.

"FA provides a measure of how intact the white matter is," said Lea Alhilali, M.D., from the University of Pittsburgh Medical Center. "The lower the FA value, the more injured the white matter is."

When Dr. Alhilali and colleagues compared the DTI results, they found that the concussion patients with vestibular symptoms had decreased FA values in brain regions not previously suspected to be involved in post-traumatic vestibulopathy.

"Patients with vestibular symptoms had white matter injury in the cerebellar area, which is known to control balance and movement, and also in the fusiform gyri, a brain area that integrates the visual fields of the left and right eye and is important to spatial orientation," she said.

The findings appear to show a connection between vestibulopathy and regional brain damage, Dr. Alhilali added.

"Vestibulopathy was previously thought to be related to the inner ear structure," she said. "What's unique about our study is that it shows that, in these patients, there is also injury to the brain itself."

The researchers also found that injury to the cerebellar area was associated with a lengthier recovery time.

The findings have the potential to change the clinical management of vestibulopathy in concussion patients, Dr. Alhilali said. For example, DTI results could be used alongside neurocognitive testing to help determine a patient's prognosis and begin appropriate treatments.

"Vestibular therapy is often very effective," Dr. Alhilali said. "Using DTI findings, we can treat patients earlier and get them back to a baseline state much sooner."

The researchers have two goals in the near term, Dr. Alhilali said. First they want to identify brain injuries associated with other post-concussion symptoms, and then they hope to conduct prospective studies to track patients from shortly after their concussions through recovery.

"Concussion is not just one pathology, but many different injuries with different symptoms," Dr. Alhilali said. "Not every case is the same, and we need to treat each patient individually."

###

"Detection of Central White Matter Injury Underlying Vestibulopathy after Mild Traumatic Brain Injury." Collaborating with Dr. Alhilali were Karl Yaeger, M.D., Michael Collins, Ph.D., and Saeed Fakhran, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.

Linda Brooks | Eurek Alert!

Further reports about: MRI Radiological cerebellar injuries injury matter symptoms treatments

More articles from Medical Engineering:

nachricht Wireless power can drive tiny electronic devices in the GI tract
28.04.2017 | Brigham and Women's Hospital

nachricht Artificial intelligence may help diagnose tuberculosis in remote areas
25.04.2017 | Radiological Society of North America

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>