Commenting on the results, interventional cardiology specialist, Professor Franz Eberli from the University Hospital Zurich (Switzerland) and official spokesperson for the European Society of Cardiology, said:
“In addition to the ABSORB study presenting the longest ever follow up data for a bioabsorbable stent, the investigators used multiple imaging systems, including Optical Coherence Tomography. This technical advance has allowed them to get really detailed images of the intra coronary structures for the first time. What really impressed me was the smoothness of the vessel wall at two years, and images showing the stents had disappeared to a great extent, which was a very promising finding.
The study showed an overall 19 % loss in luminal diameter at 18 months and an angiographic in- stent late loss of 0.48mm at two years. These results fall intermediate between those commonly seen for bare metal stents (which typically have an in stent late loss of 1.0 mm), and drug eluting stents (which typically have an in-stent late loss of 0.15 to 0.3 mm). But the upside of this bioabsorbable stent data is that patients don't appear to be getting any in-stent thrombosis here.
Since in-stent late loss increased by only 0.05 mm between 6 months and two years, the most probable explanation for the in-stent late loss is early recoil after stent implantation. This indicates that this bioabsorbable stent initially is not exerting enough radial force to keep the vessels perfectly open. The challenge facing stent designers is to achieve a balance between sufficient radial strength, and a structure that can be reabsorbed in a reasonable time period. Industry is already acting on this data and looking to produce stronger second generation bioabsorbable stents by developing novel stent designs that retain integrity and radial strength for a longer time period.
The fact that vasomotion (the ability to undergo vasodilation and vasoconstriction) was restored in response to vasoactive agents in the stented vessel segment was a really good sign. It shows that after two years the physiological function of the stented part of the vessel has been almost completely restored, and that patients will not get any symptoms of angina or limitations in physical activity. In contrast, for first generation drug eluting stents, studies have shown “paradoxical vasoconstriction” in the area of the stent, where the vessel constricts instead of opening during exercise.
This is a proof of principle study that teaches us a lot about the way bioabsorbable stents work and affect remodelling of the stented vessel segment. But with only 30 patients included in the study, numbers are too small to show us if the technology is safe. Furthermore the study was only performed in patients with single de novo coronary lesions, who are considered by far the most straight forward cases. The study doesn't show us if the new stent will work in real world situations of patients with long lesions, calcification or bifurcations.”
ESC Press Office | EurekAlert!
Further reports about: > ABSORB > Bare metal Stents > Bioabsorbable stents > angiographic in-stent > bioabsorbable everolimus coronary stent > in-stent thrombosis > interventional cardiology > intra coronary structures > multiple imaging systems > paradoxical vasoconstriction > vasoconstriction > vasodilation > vasomotion
3-D visualization of the pancreas -- new tool in diabetes research
15.03.2017 | Umea University
New PET radiotracer identifies inflammation in life-threatening atherosclerosis
02.03.2017 | Society of Nuclear Medicine
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
27.03.2017 | Earth Sciences
27.03.2017 | Life Sciences
27.03.2017 | Life Sciences