Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale researchers uncover secrets of salmonella's stealth attack

20.04.2009
A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers report in the April 17 issue of the journal Cell.

This evolutionary slight-of-hand sheds new insights into the lethal tricks of Salmonella, which kills more than 2 million people a year.

"In evolutionary terms, this hijacking of cellular machinery to diversify the function of a bacterial protein is mind boggling,'' said Jorge Galan, senior author of the paper and the Lucille P. Markey Professor of Microbial Pathogenesis and Cell Biology and chair of microbial pathogenesis at Yale.

Salmonella causes disease when it takes control of cells lining the intestinal track using its own specialized "nano-syringe" called a type III secretion system. Using this structure, Salmonella injects bacterial proteins that mimic proteins of the host cell and help the pathogen avoid destruction.

The Yale study describes the crucial role a bacterial protein called SopB plays in both Salmonella's forced entry into the cell and its subsequent internal camouflage act. First, SopB works within the external membrane of the cell, called the plasma membrane, to coax the cell into taking in the pathogen, which is then encapsulated within a tiny bubble-like compartment called a vesicle.

SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that degrades proteins. In order to accomplish this, SopB must move from the plasma membrane of the cell to the membrane of the internal vesicle containing the pathogen. The Yale group found that Salmonella coaxes the cell to "mark" the SopB protein with a tag called ubiquitin. Addition of this tag makes the bacterial protein recognizable to the cellular machinery that normally moves proteins from the plasma membranes to internal vesicles.

"These studies provide a unique insight into the mechanisms by which this important pathogen causes disease," Galan said. "In addition, this finding may point to a novel paradigm that may be applicable to other important pathogens."

Other Yale authors of the paper are Jayesh C. Patel, Karsten Hueffer, and Tukiet T. Lam.

The study was funded by a grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health

Bill Hathaway | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>