Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale researchers develop a way to monitor engineered blood vessels as they grow in patients

01.12.2011
New research in the FASEB Journal suggests magnetic resonance imaging allows researchers to study and monitor how new vessels perform while they are 'under construction' in patients

Using magnetic resonance imaging (MRI) and nanoparticle technology, researchers from Yale have devised a way to monitor the growth of laboratory-engineered blood vessels after they have been implanted in patients. This advance represents an important step toward ensuring that blood vessels, and possibly other tissues engineered from a patient's own biological material, are taking hold and working as expected. Until now, there has been no way to monitor the growth and progress of engineered tissues once they were implanted. This research was published in the December 2011 issue of the FASEB Journal (http://www.fasebj.org).

"We hope that the important findings from our study will serve as a valuable tool for physicians and scientists working to better understand the biological mechanisms involved in tissue engineering," said Christopher K. Breuer, M.D., co-author of the study from the Interdepartmental Program in Vascular Biology and Therapeutics at Yale University School of Medicine in New Haven, CT. "Resulting advances will hopefully usher in a new era of personalized medical treatments where replacement vessels are specifically designed for each patient suffering from cardiac anomalies and disease."

To make this advance, scientists used two different groups of cells to make tissue-engineered blood vessels. In the first group, the cells were labeled with the MRI contrast agent. In the second group, the cells were normal and did not have an MRI label. Cells from each group were then used to create separate laboratory-engineered blood vessels, which were implanted into mice. The purpose was to see whether the laboratory-engineered blood vessels made from cells that were labeled with the contrast agent would indeed be visible on MRI and to make sure that the addition of the contrast agent did not negatively affect the cells or the function of the laboratory-engineered vessels. Researchers imaged the mice with MRI and found that it was possible to track the cells labeled with contrast agent, but not possible to track the cells that were not labeled. This suggests that using MRI and cellular contrast agents to study cellular changes in the tissue-engineered blood vessels after they are implanted is an effective way to monitor these types of vessels.

"This is great news for patients with congenital heart defects, who have to undergo tissue grafting, but that's only the tip of the scalpel," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "As we progress toward an era of personalized medicine—where patients' own tissues and cells will be re-engineered into replacement organs and treatments—we will need noninvasive ways to monitor what happens inside the body in real time. This technique fulfills another promise of nanobiology."

Receive monthly highlights from the FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB) and celebrates its 25th anniversary in 2011. Over the past quarter century, the journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information.

FASEB comprises 24 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improve—through their research—the health, well-being and productivity of all people. FASEB's mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Jamie K. Harrington, Halima Chahboune, Jason M. Criscione, Alice Y. Li, Narutoshi Hibino, Tai Yi, Gustavo A. Villalona, Serge Kobsa, Dane Meijas, Daniel R. Duncan, Lesley Devine, Xenophon Papademetri, Toshiharu Shin'oka, Tarek M. Fahmy, and Christopher K. Breuer.

Determining the fate of seeded cells in venous tissue-engineered vascular grafts using serial MRI. FASEB J. December 2011 25:4150-4161; doi:10.1096/fj.11-185140 ; http://www.fasebj.org/content/25/12/4150.abstract

Cody Mooneyhan | EurekAlert!
Further information:
http://www.fasebj.org

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>