Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

World's first handmade cloned transgenic sheep born in China

19.04.2012
Chinese scientists from BGI, the world's largest genomics organization, together with the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS), and Shihezi University, Xinjiang province, made a significant breakthrough in animal cloning.
The world's first transgenic sheep produced with a simplified technique, handmade cloning, was successfully born at 12:16pm, March 26, 2012, in Xinjiang Uygur Autonomous Region, China. The project was also supported by the Animal Science Academy of Xinjiang.

"The transgenic sheep is named 'Peng Peng' (after the identical given names of the two cloners), his birth weight was 5.74 kg." said excitedly Dr. Yutao Du, Director of BGI Ark Biotechnology Co., LTD. (BAB), one of BGI's affiliates focusing on large scale production of transgenic and cloned animals. "Peng Peng is developing normally and appears healthy" she added.

The project has been launched more than two years ago. Apart from the general inefficiency of cloning (only a small fraction of the reconstructed embryos develop to healthy offspring) cloners had to overcome additional difficulties including the special climate and compromised laboratory environment with very basic instruments. Accordingly, an innovative simplified technique called Handmade Cloning (HMC) was used, with less demand for sophisticated equipment, simplified procedures, lower costs and higher production efficiency. In 2009, donor cells were collected from a Chinese Merino sheep, and by genetic manipulation a transgenic cell line was established. After numerous attempts, the HMC system for sheep cloning was successfully established in October 2011. The transfer of the produced embryos has eventually led to the present achievement.

The genetic modification may result in improved meat quality by increasing the unsaturated fatty acid content. According to the researchers, the gene associated withù-3 poly unsaturated fatty acid (ù-3PUFA) was successfully transferred into Peng Peng. ù-3PUFAs serve as essential fatty acids for humans reducing the risk of coronary heart disease and supporting the normal development of the brain, eye and neurons. "The birth of Peng Peng means that people could absorb ù-3PUFAs by drinking milk or eating meat in the future." said Dr. Du, "The most difficult task has been accomplished, the transgenic sheep production platform is established, we are ready for the industrial-scale development."

Since HMC was introduced in 2001, offspring of several important species including cattle, pig, goat and water buffalo have been produced by using this technique. The procedure may contribute to efforts to save endangered species and to produce medicines for human diseases through transgenic animals.

Last year, BGI has made great achievements on cloned transgenic mini-pigs and micro-pigs. Last August, a heroic pig, named Zhu Jiangqiang (Strong-Willed Pig), who had survived more than a month buried under rubble after the 2008 earthquake in China's Sichuan province was also cloned, producing 6 piglets identical with the famous animal. "With each new species cloned, we learn more about the possible contribution of HMC to improve the health of animals and humans." said Dr. Du. "I expect more breakthroughs on transgenic and cloned animal research in the foreseeable future."
About BGI Ark Biotechnology Co., LTD

BGI Ark Biotechnology Co., LTD. Shenzhen (BAB), affiliated to BGI, is a high-tech enterprise, mainly focusing on mass production of transgenic and cloned animals.

Based on a core technology named Handmade Cloning (HMC), BAB has established a reliable and efficient standard production system, including vector construction, screening of genetically modified cell lines, reconstruction of cloned embryos, embryo transfer, among others.

Compared with traditional cloning, the benefits of handmade cloning are great. Low equipment costs, a simple and rapid procedure and a higher in vitro efficiency are valuable for large scale research in medical and agricultural sciences.

For more information about BAB, please visit www.bab-genomics.com.
About BGI

BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.

BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 170 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, have sequenced the human Gut Metagenome, and a significant proportion of the genomes for the 1000 Genomes Project.

For more information about BGI, please visit www.genomics.cn

Jia Liu | EurekAlert!
Further information:
http://www.genomics.cn

Further reports about: BGI Biotechnology Chinese herbs Cloning Genom HMC Handmade Ltd Xinjiang fatty acid saturated fat saturated fatty acid

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>