The study, published in the journal Acta Oncologica, shows that the increased risk of ovarian cancer is linked to a known mutation in women with breast cancer in Western Sweden.
The research team had previously identified a special mutation in the breast cancer gene BRCA1 originating with some distant forefather on Sweden's West Coast many generations back. The mutation is often seen in families where three or more members develop breast and/or ovarian cancer and where someone under 50 is diagnosed with breast and/or ovarian cancer.
"Our previous research showed that Western Swedish women with breast cancer are more likely to develop ovarian cancer than women diagnosed with breast cancer in other parts of the country," says Per Karlsson, associate professor from the Department of Oncology and leader of the research team at the Cancer Genetics Clinic at Sahlgrenska University Hospital.
Most ovarian tumours are benign, especially in younger women, but more than 700 women in Sweden are diagnosed with ovarian cancer each year, some 30-40 of them as a result of the Western Swedish BRCA1 mutation. Now the researchers have shown that the increased risk of ovarian cancer among women diagnosed with breast cancer is due solely to this known mutation in the breast cancer gene BRCA1. Their research results reveal that women diagnosed with breast cancer who do not have this mutation do not run an increased risk of ovarian cancer.
"This means that we can focus our investigations and screening on families where many relatives have had breast and ovarian cancer," says Karlsson.
As this elevated risk of ovarian cancer affects only a very small proportion of women with breast cancer, the next step is to provide patients with clearer information about the risks associated with breast cancer when visiting the doctor.
"There is also research under way in the cancer genetics field which may mean that, in future, patients can receive more specific screening, and that cancer patients can expect a more personalised treatment," says Karlsson, who believes that this work could lead to fewer screenings and fewer side-effects from cancer treatments.BREAST CANCER
Authors: Zakaria Einbeigi, Charlotta Enerbäck, Arne Wallgren, Margareta Nordling and Per Karlsson
Helena Aaberg | idw
Seeking balanced networks: how neurons adjust their proteins during homeostatic scaling.
24.10.2016 | Max-Planck-Institut für Hirnforschung
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences