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Only women with Western Swedish breast cancer gene run higher risk of ovarian cancer

Previous research has shown that women with breast cancer are more likely than other women to develop ovarian cancer, but now researchers from the Sahlgrenska Academy at the University of Gothenburg, Sweden, have shown that actually only women with a known Western Swedish mutation behind hereditary breast cancer run this increased risk of ovarian cancer.

The study, published in the journal Acta Oncologica, shows that the increased risk of ovarian cancer is linked to a known mutation in women with breast cancer in Western Sweden.

The research team had previously identified a special mutation in the breast cancer gene BRCA1 originating with some distant forefather on Sweden's West Coast many generations back. The mutation is often seen in families where three or more members develop breast and/or ovarian cancer and where someone under 50 is diagnosed with breast and/or ovarian cancer.

"Our previous research showed that Western Swedish women with breast cancer are more likely to develop ovarian cancer than women diagnosed with breast cancer in other parts of the country," says Per Karlsson, associate professor from the Department of Oncology and leader of the research team at the Cancer Genetics Clinic at Sahlgrenska University Hospital.

Most ovarian tumours are benign, especially in younger women, but more than 700 women in Sweden are diagnosed with ovarian cancer each year, some 30-40 of them as a result of the Western Swedish BRCA1 mutation. Now the researchers have shown that the increased risk of ovarian cancer among women diagnosed with breast cancer is due solely to this known mutation in the breast cancer gene BRCA1. Their research results reveal that women diagnosed with breast cancer who do not have this mutation do not run an increased risk of ovarian cancer.

"This means that we can focus our investigations and screening on families where many relatives have had breast and ovarian cancer," says Karlsson.

As this elevated risk of ovarian cancer affects only a very small proportion of women with breast cancer, the next step is to provide patients with clearer information about the risks associated with breast cancer when visiting the doctor.

"There is also research under way in the cancer genetics field which may mean that, in future, patients can receive more specific screening, and that cancer patients can expect a more personalised treatment," says Karlsson, who believes that this work could lead to fewer screenings and fewer side-effects from cancer treatments.

Around 7,000 people in Sweden develop breast cancer each year, and it is the most common form of cancer in Swedish women. Of these cases, an estimated 100-150 are women diagnosed with breast cancer due to the Western Swedish BRCA1 mutation. Breast cancer can be caused by hormonal and hereditary factors, among others. It affects mainly elderly women and is uncommon among younger women. Treatments include surgery, radiotherapy, hormone therapy and chemotherapy. More and more breast cancer patients in Sweden are managing to beat the disease, and almost three-quarters now survive.
For more information, please contact:
Per Karlsson, associate professor at the Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, and consultant at Sahlgrenska University Hospital, tel: +46 31 342 86 52, e-mail:
Journal: Acta Oncologica
Title of article: BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - a population based study from the Western Sweden Health Care region

Authors: Zakaria Einbeigi, Charlotta Enerbäck, Arne Wallgren, Margareta Nordling and Per Karlsson

Helena Aaberg | idw
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Further reports about: BRCA1 breast cancer gene mutation ovarian cancer ovarian tumours

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