Scientists at the University of Gothenburg, Sweden, have discovered that one type of the body’s water channels can be modified such that it becomes more stable , which may be significant in the treatment of several diseases.
“It’s important to understand how the water channels, which are known as ‘aquaporins’, in the body work, since they control many of the processes in our cells and tissues. They also determine what is to be transported into and out of the cell, and they are thus highly significant in the development of new treatments for various diseases, such as eczema, cerebral oedema, obesity and cancer”, says Kristina Hedfalk of the Department of Chemistry at the University of Gothenburg.Aquaporins are vital
The research group, which consists of Fredrik Öberg, Jennie Sjöhamn, Gerhard Fischer, Andreas Moberg, Anders Pedersen, Richard Neutze and Kristina Hedfalk, describes their studies of one of the most recently discovered aquaporins in an article in the scientific journal The Journal of Biological Chemistry. This aquaporin, AQP10, is preferentially found in the intestine, and is particularly interesting since it transports both water and sugar alcohols.Carbohydrates stabilise the water channel
The article Glycosylation Increases the Thermostability of Human Aquaporin 10 Protein has been published in the September edition of The Journal of Biological Chemistry.
Title: Glycosylation Increases the Thermostability of Human Aquaporin 10 ProteinFor more information, please contact: Kristina Hedfalk
Helena Aaberg | idw
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