Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technology facilitates studies of brain cells in stroke

22.03.2010
A mini-laboratory that makes it possible, among other things, to study how brain cells in stroke patients are affected by lack of oxygen is being developed by a research team at Luleå University of Technology (LTU) in Sweden.

Lab on a Chip is what the scientists are calling their mini-lab, which is expected to facilitate studies of all sorts of biological cells and how they are affected by different medicines, chemical substances, etc.

The researchers in medical technology at Luleå University of Technology have wind in their sails. New technological solutions are needed to help meet Europe's rapidly growing needs for healthcare.

The development of the mini-lab Lab on a Chip is one of 22 projects being pursued within the framework of the Center for Medical Technology and Physics, CMTF, a joint initiative involving Luleå University of Technology and Umeå University.

Professor Olof Lindahl and his research associate Kerstin Ramser in Luleå are developing a so-called micro-flow system to study, for instance, how the vital oxygen-bearing protein neuroglobin, which is found in brain cells, is affected by the lack of oxygen that occurs in stroke.

Neuroglobin was discovered in 2000 by a German research team and occurs primarily in brain cells. Overproduction of neuroglobin in the brains of mice has been shown to mitigate the consequences of damage relating to oxygen deficiency in stroke.

"Today there are no really good methods for studying how individual cells signal under oxygen-poor conditions," says Kerstin Ramser. "One advantage of the new technology we use is that it is now possible to select and isolate specific cells in a controlled environment."

The Lab on a Chip that the Luleå researchers have produced measures 2 X 6 cm and fits on the specimen glass of a microscope. This makes it possible to reduce the size of the sample, in blood analysis, for example.

"What we are studying is the electrophysiological activity of brain cells, that is, their capacity to communicate with other cells under oxygen-poor and entirely oxygen-free conditions," says Kerstin Ramser.

To be able to study how brain cells are affected by stroke, researchers pump fluids with varying levels of oxygen content into channels in the mini-lab. The channels are extremely small, corresponding to one third of the thickness of a hair. Once the fluid has been pumped into the system, the cell sample is introduced. With the help of optical tweezers, which use laser beams to capture and move cells, the scientists can select and isolate a specific cell in order to study how it behaves in various oxygen mixtures.

"Enhance the quality of care today is largely a matter of developing new technologies that help us advance our knowledge of the major diseases, such as cancer, stroke, or Parkinson's," says Kerstin Ramser.

There are some 8 professors and 20-25 researchers in the field of medical technology at Luleå University of Technology today. Much of the medical technology research conducted at Luleå University of Technology is done together with researchers from Umeå University in an interdisciplinary collaboration where Luleå provides the technological expertise and Umeå the medical competence.

The research center CMTF involves not only the two universities but also the Norrbotten and Västerbotten County Councils, companies, and researchers from Sweden, Japan, Germany, Spain, and other countries. They develop products and services for more secure healthcare.

Their work is partly funded by EU Goal2. A researcher-owned company for developing businesses, financed by the County Administrations, Innovation Bridge North, LTU Holding, Uminova Innovation, and the parties involved, is tied to the Center.

Contact: Professor Olof Lindahl, mobile phone: +46 (0)70 6060 04 14, olof.lindahl@ltu.se or Associate Professor Kerstin Ramser, phone: +46 (0)920 - 49 16 48, kerstin.ramser@ltu.se

Pressofficer Åsa Svedjeholm; Asa.Svedjeholm@ltu.se; +46-703 39 16 28

Åsa Svedjeholm | idw
Further information:
http://www.vr.se

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>