Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Syracuse University biologist discovers key regulators for biofilm development

27.06.2011
They can be found everywhere—organized communities of bacteria sticking to surfaces both inside and outside the body. These biofilms are responsible for some of the most virulent, antibiotic-resistant infections in humans; however, scientific understanding of how these communities develop is lacking.

A recent study led by a Syracuse University biologist sheds new light on the process. The scientists discovered that a complex cascade of enhancer binding proteins (EBPs) is responsible for turning on genes that initiate the formation of a biofilm. The study was published June 13 in the Proceedings of the National Academy of Sciences, one of the world's most-cited multidisciplinary scientific serials.

The National Science Foundation is funding the research (link to article: http://www.pnas.org/content/early/2011/06/07/1105876108.abstract?sid=dbfeeb94-6f1e-44c8-b610-d39a98acbd88).

"We've discovered a complex regulatory cascade of EBPs that is designed to be highly responsive to environmental signals," says Anthony Garza, associate professor of biology in SU's College of Arts and Sciences and corresponding author for the study. "The regulatory circuit we identified is very different from that which has previously been seen." Garza's research team includes scientists from the University of Miami School of Medicine, the University of Wisconsin-Madison, and Stanford University School of Medicine.

Garza's team discovered that the regulatory network that signals biofilm development is quite complex and akin to that which is normally found in higher organisms. "Bacterial cells that form biofilms require cooperative behavior similar to cells in more complex organisms," he says. "We knew EBPs were important in initiating biofilm development, and that there was a connection between EBPs and specific biofilm genes. But we didn't know how the EBP regulatory circuit was put together." Garza's team has also begun to identify the signals that activate the EBP circuitry and the corresponding biofilm genes. Those studies are forthcoming.

The work to uncover how biofilms are genetically initiated is key to developing new ways to prevent and/or treat infected surfaces, Garza says. Bacteria are stimulated to organize into biofilms by several mechanisms, including starvation, high nutrient levels, tissue recognition, and quorum or cell-density signaling. Because it takes a lot of energy to organize, bacteria need to be certain conditions are optimal before initiating the biofilm process.

For example, Garza explains, bacterial cells can recognize desirable host tissue, such as lung tissue. Once there, the cells look around to see if enough of their buddies are around to form a biofilm. In this case, both tissue recognition and quorum signaling is at work in initiating the process.

"Unfortunately, biofilms can be up to a thousand times more antibiotic resistant than free-living bacteria," Garza says. "Once established, biofilms are extremely resistant to killing agents—chemicals, cleaners, antibiotics. The key to preventing their development is in understanding how they get started."

The College of Arts and Sciences at Syracuse University is a highly selective liberal arts college at the center of a major research university. With a curriculum emphasizing interdisciplinary learning, research, service, and enterprise, The College prepares students for the global workplace and for continued study in graduate and post-baccalaureate professional programs.

Judy Holmes | EurekAlert!
Further information:
http://www.syr.edu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>