How do strokes occur? What tends to happen is that a clot blocks the blood vessels supplying the brain. The brain then becomes starved of blood and oxygen, as a consequence of which nerve cells start to die.
"A massive import of calcium ions into these nerve cells plays a major role in the death of the cells," explains Professor Bernhard Nieswandt from the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg. But the exact details of this process have been unclear, until now.
Sensor protein drives up calcium levels
The regulation of the inflow of calcium into the nerve cells has always been something of a mystery. One possible calcium regulator is the sensor protein STIM1: in blood cells it measures the concentration of calcium. If the level is too low, it stimulates import. It was also suspected that STIM1 played a similar role for nerve cells.
However, contrary to prevailing assumptions, it is not STIM1 that opens the floodgates for calcium during cerebral ischemia. Responsibility lies instead with STIM2 - a related protein to which science has always attributed a more minor role. This is the report given by Bernhard Nieswandt with colleagues from Würzburg and Leipzig in the journal Science Signaling.
Nerve cells fare better without STIM2
The research team discovered that nerve cells with no STIM2 survive an inadequate supply of blood or oxygen far more successfully than normal nerve cells. This evidence was obtained using cell cultures and mice. The areas of the brain left damaged by a stroke were reduced by more than half in the absence of STIM2.
Possible therapy: blockade of STIM2
What does this finding mean for stroke patients? Nothing yet. But it offers scientists a new starting point that they may be able to use to improve therapy and prevention.
"If the STIM2 protein can be blocked by a drug, this may alleviate the consequences of an ischemic stroke. Stroke patients often suffer paralyses as well as losses of sensation and impaired speech for which current therapies can only offer inadequate treatment," explains Professor Guido Stoll from the Department of Neurology at the University of Würzburg.
As their next step, the researchers wish to investigate which calcium channels in the nerve cells are opened by STIM2 and how this process can be influenced using substances.
Scientists from Würzburg and Leipzig involved
The following scientists from the University of Würzburg were involved in the work: Alejandro Berna-Erro, Attila Braun, David Stegner, and Bernhard Nieswandt from the Rudolf Virchow Center for Experimental Biomedicine/DFG Research Center; Guido Stoll, Christoph Kleinschnitz, Michael Schuhmann, and Sven Meuth from the Department of Neurology; and Thomas Wultsch from the Department of Psychiatry. Also involved were Robert Kraft and Jens Eilers from the Institute of Physiology at the University of Leipzig.
"STIM2 Regulates Capacity Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death", Alejandro Berna-Erro, Attila Braun, Robert Kraft, Christoph Kleinschnitz, Michael K. Schuhmann, David Stegner, Thomas Wultsch, Jens Eilers, Sven G. Meuth, Guido Stoll, Bernhard Nieswandt, Science Signaling 2009, Vol. 2, Issue 93, p. ra67, Oct 20, DOI: 10.1126/scisignal.2000522
Prof. Dr. Bernhard Nieswandt, phone +49 931 31-80406, email@example.com
Robert Emmerich | idw
Copper hydroxide nanoparticles provide protection against toxic oxygen radicals in cigarette smoke
29.05.2017 | Johannes Gutenberg-Universität Mainz
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences