Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Soap Bubbles for Treating Stenosed Blood Vessels

11.03.2016

Liposomes are currently used as drug delivery vehicles but recognized by the immune system. Scientists from the universities of Basel and Fribourg have shown that special artificial liposomes do not elicit any reaction in human and porcine sera as well as pigs. The study was published in the Journal Nanomedicine: Nanotechnology, Biology, and Medicine.

Liposomes are soap-bubble-like nanocontainers made of a double phospholipid membrane that shields off an inner aqueous compartment. In a lenticular form, as developed by Professor Andreas Zumbühl’s team at the Department of Chemistry at the University of Fribourg, they are promising candidates for drug delivery to constricted coronary arteries. Here, the blood flows through the stenosed artery segments with high velocity and is subjected to enhanced shear forces. Under these conditions, the liposomes open and release their content.


The drug molecules (red) are embedded in a water-filled cavity inside of the phopholipid vesicle.

University of Basel/University of Fribourg

Unfortunately, the immune system does recognize these liposomes as foreign bodies. The activation of the immune system may lead to a pseudo-allergy. Earlier studies have shown that negative effects are found in up to 30 percent of the cases. Even using clinically approved liposomal dugs it is possible to find anaphylactic shocks, which can be highly toxic for the treated patient.

No Reaction in Pig Studies

A team of researchers led by Prof. Bert Müller from the Biomaterials Science Center of the University of Basel and Prof. Andreas Zumbühl from the Department of Chemistry at the University of Fribourg has tested artificial phospholipid vesicles (Pad-PC-Pad vesicles) for their potential as drug delivery nanocontainers. Surprisingly, these liposomes did not spur any reaction neither in blood serum of pigs nor humans.

In a next step, the vesicles were tested in living organisms. The researchers injected three Yorkshire pigs with Pad-PC-Pad suspensions and monitored the heart rate, the electrocardiogram and the blood pressures. Even at high doses the pigs showed no or negligible reactions. The biopsies of pig tissues showed no toxic changes in kidneys, lungs, heart, and liver. “The study shows that Pad-PC-Pad liposomes are not inducing direct or indirect anaphylactic reactions, even at high dosages”, says Professor Bert Müller of the University of Basel. “These are highly unexpected results could have a high impact of future treatments of atherosclerosis.”

According to the World Health Organization WHO coronary artery diseases are responsible for 30 % of deaths worldwide. In the case of constricted coronary arteries the conditions often gets worse during the transport of the patient to the hospital, showing the need for medication that efficiently covers the pre-hospital segment. Pad-PC-Pad vesicles therefore show high potential because, in contrast to existing liposomes, they do not elicit a significant immune response.

Original source
Simon Bugna, Marzia Buscema, Sofiya Matviykiv, Rudolf Urbanics, Andreas Weinberger, Tamas Meszaros, Janos Szebeni, Andreas Zumbuehl, Till Saxer, and Bert Müller
Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro
Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) | doi: 10.1016/j.nano.2015.12.364

Further information
Prof. Bert Müller, University of Basel, Biomaterials Science Center, phone +41 61 265 9660, email: bert.mueller@unibas.ch
Prof. Andreas Zumbühl, University of Fribourg, Department of Chemistry, phone +41 26 300 8794, email: andreas.zumbuehl@unifr.ch

Weitere Informationen:

https://www.unibas.ch/en/News-Events/News/Uni-Research/Soap-Bubbles-for-Treating...

Reto Caluori | Universität Basel

Further reports about: coronary arteries immune system liposomes vesicles

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>