Liposomes are currently used as drug delivery vehicles but recognized by the immune system. Scientists from the universities of Basel and Fribourg have shown that special artificial liposomes do not elicit any reaction in human and porcine sera as well as pigs. The study was published in the Journal Nanomedicine: Nanotechnology, Biology, and Medicine.
Liposomes are soap-bubble-like nanocontainers made of a double phospholipid membrane that shields off an inner aqueous compartment. In a lenticular form, as developed by Professor Andreas Zumbühl’s team at the Department of Chemistry at the University of Fribourg, they are promising candidates for drug delivery to constricted coronary arteries. Here, the blood flows through the stenosed artery segments with high velocity and is subjected to enhanced shear forces. Under these conditions, the liposomes open and release their content.
Unfortunately, the immune system does recognize these liposomes as foreign bodies. The activation of the immune system may lead to a pseudo-allergy. Earlier studies have shown that negative effects are found in up to 30 percent of the cases. Even using clinically approved liposomal dugs it is possible to find anaphylactic shocks, which can be highly toxic for the treated patient.
No Reaction in Pig Studies
A team of researchers led by Prof. Bert Müller from the Biomaterials Science Center of the University of Basel and Prof. Andreas Zumbühl from the Department of Chemistry at the University of Fribourg has tested artificial phospholipid vesicles (Pad-PC-Pad vesicles) for their potential as drug delivery nanocontainers. Surprisingly, these liposomes did not spur any reaction neither in blood serum of pigs nor humans.
In a next step, the vesicles were tested in living organisms. The researchers injected three Yorkshire pigs with Pad-PC-Pad suspensions and monitored the heart rate, the electrocardiogram and the blood pressures. Even at high doses the pigs showed no or negligible reactions. The biopsies of pig tissues showed no toxic changes in kidneys, lungs, heart, and liver. “The study shows that Pad-PC-Pad liposomes are not inducing direct or indirect anaphylactic reactions, even at high dosages”, says Professor Bert Müller of the University of Basel. “These are highly unexpected results could have a high impact of future treatments of atherosclerosis.”
According to the World Health Organization WHO coronary artery diseases are responsible for 30 % of deaths worldwide. In the case of constricted coronary arteries the conditions often gets worse during the transport of the patient to the hospital, showing the need for medication that efficiently covers the pre-hospital segment. Pad-PC-Pad vesicles therefore show high potential because, in contrast to existing liposomes, they do not elicit a significant immune response.
Simon Bugna, Marzia Buscema, Sofiya Matviykiv, Rudolf Urbanics, Andreas Weinberger, Tamas Meszaros, Janos Szebeni, Andreas Zumbuehl, Till Saxer, and Bert Müller
Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro
Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) | doi: 10.1016/j.nano.2015.12.364
Prof. Bert Müller, University of Basel, Biomaterials Science Center, phone +41 61 265 9660, email: email@example.com
Prof. Andreas Zumbühl, University of Fribourg, Department of Chemistry, phone +41 26 300 8794, email: firstname.lastname@example.org
Reto Caluori | Universität Basel
Transforming plant cells from generalists to specialists
07.12.2016 | Duke University
What happens in the cell nucleus after fertilization
06.12.2016 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Earth Sciences
07.12.2016 | Earth Sciences
07.12.2016 | Materials Sciences