Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Skin and Immune System Influence Salt Storage and Regulate Blood Pressure

07.09.2012
High blood pressure is responsible for many cardiovascular diseases that are the leading cause of death in industrialized countries.

High salt intake has long been considered a risk factor, but not every type of high blood pressure is associated with high salt intake. This has puzzled scientists for a long time.

New findings by Professor Jens Titze (Vanderbilt University, USA and the University of Erlangen) now point to previously unknown mechanisms. Accordingly, the skin and the immune system play an important role in the regulation of the sodium balance and hypertension, as he reported at the 1st ECRC Franz Volhard Symposium at the Max Delbrück Center (MDC) on September 7, 2012 in Berlin.

The water and salt balance of the body is of great importance for blood pressure. The decisive factor is the kidney, which regulates how much water is retained in the body and how much is excreted. In this way it regulates the volume of blood and thus influences blood pressure. However, new findings by Professor Titze, one of the leading experts in the field, show that organs and systems of the body that hitherto were not associated with water and salt balance have an influence on blood pressure: the skin and the immune system.

Professor Titze showed that sodium can be stored in the connective tissue of the skin. “The sodium concentration can be higher in the skin than in blood. This means that not only the kidney regulates sodium balance but that there must be additional mechanisms,” the researcher explained. His research group demonstrated that the immune system plays an important role in this mechanism: A specific type of immune cells, the macrophages – literally “big eaters” in Greek – recognize high sodium levels in the skin. They subsequently activate a gene that in turn ensures that the vascular endothelial growth factor (VEGF-C) is released in large amounts into the skin. VEGF-C controls the growth of lymphatic vessels that transport fluid and sodium. If this factor is released in higher amounts, lymphatic vessels grow into the skin and ensure that the stored sodium can be transported away again.
In animal experiments Professor Titze’s research team blocked this mechanism. As a result, the rats and mice in the experiment developed high blood pressure. “The immune cells apparently regulate salt balance and blood pressure,” Professor Titze said. “In addition, data from a first clinical study showed that large amounts of salt are stored in the skin of patients with high blood pressure.”

Contact:
Barbara Bachtler
Press Department
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association
Robert-Rössle-Straße 10; 13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96; Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | Max-Delbrück-Centrum
Further information:
http://www.mdc-berlin.de/

More articles from Life Sciences:

nachricht Show me your leaves - Health check for urban trees
12.12.2017 | Gesellschaft für Ökologie e.V.

nachricht Liver Cancer: Lipid Synthesis Promotes Tumor Formation
12.12.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>