Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Silk-based optical waveguides meet biomedical needs

01.09.2009
There is a growing need for biocompatible photonic components for biomedical applications – from in vivo glucose monitoring to detecting harmful viruses or the telltale markers of Alzheimer's. Optical waveguides are of particular interest because of their ability to manipulate and transport light in a controlled manner in a variety of configurations.

In an article featured on the cover of Advanced Materials, researchers at Tufts University and the University of Illinois at Urbana-Champaign demonstrated a new method for fabricating silk-based optical waveguides that are biocompatible, biodegradable and can be readily functionalized with active molecules. The Tufts-UIUC team successfully demonstrated light guiding through this new class of waveguides created by direct ink writing using Bombyx mori silk fibroin inks.

"In many biomedical applications, waveguides must interface directly with living cells and tissues, requiring the waveguide constituent to be biocompatible. Biodegradability is also desirable," said Tufts' Fiorenzo Omenetto, professor of biomedical engineering in the School of Engineering and professor of physics in the School of Arts and Sciences. "The use of a biocompatible, biodegradable polymer like silk to guide light opens up new opportunities in biologically based modulation and sensing along with an opportunity to integrate light delivery within living tissue."

The research capitalized on Tufts' knowledge of silk-based biopolymers and biophotonics and the expertise of UIUC Professor Jennifer A. Lewis and graduate student Sara T. Parker in direct-write assembly to create complex planar and three-dimensional structures.

"Silks are well suited for this purpose, because they are the strongest and toughest natural fibers known," said David Kaplan, professor and chair of the biomedical engineering department at Tufts' School of Engineering. "Furthermore, the ability to biochemically functionalize or incorporate dopants into the silk-fibroin ink allows for unconventional photoactivation of the waveguides, which is not easily achieved otherwise."

Direct ink writing is a simple, inexpensive technique that does not require harsh processing steps. A computer-controlled three-axis translation stage precisely moves a syringe barrel that houses a viscous ink, which is extruded from a fine deposition nozzle under pressure. The ink flows rapidly through the nozzle, and equally rapidly solidifies upon exiting to retain a filamentary shape while maintaining sufficient optical clarity to guide light.

"Silk Fibroin Waveguides: Biocompatible Silk Printed Optical Waveguides" appeared in the June 19, 2009, issue of Advanced Materials, authored by Sara T. Parker, Peter Domachuk, Jason Amsden, Jason Bressner, Jennifer A. Lewis, David L. Kaplan, and Fiorenzo G. Omenetto.

Research funding was provided by a National Science Foundation Graduate Research Fellowship, the Defense Advanced Research Projects Agency, the Air Force Office of Scientific Research, and the US Department of Energy.

Tufts University School of Engineering is uniquely positioned to educate the technological leaders of tomorrow. Located on Tufts' Medford/Somerville campus, the School of Engineering offers a rigorous engineering education in an environment characterized by the best blending of a liberal arts college atmosphere with the intellectual and technological resources of a world-class research university. Close collaboration with the School of Arts and Sciences and the university's extraordinary collection of excellent professional schools creates a wealth of educational and research opportunities. The School of Engineering's primary goal is to educate engineers committed to the innovative and ethical application of technology in the solution of societal problems. It also seeks to be a leader among peer institutions in targeted areas of interdisciplinary research and education that impact the well-being of society, including bioengineering, sustainability and innovation in engineering education.

Tufts University, located on three Massachusetts campuses in Boston, Medford/Somerville, and Grafton, and in Talloires, France, is recognized among the premier research universities in the United States. Tufts enjoys a global reputation for academic excellence and for the preparation of students as leaders in a wide range of professions. A growing number of innovative teaching and research initiatives span all Tufts campuses, and collaboration among the faculty and students in the undergraduate, graduate and professional programs across the university's schools is widely encouraged.

Kim Thurler | EurekAlert!
Further information:
http://www.tufts.edu

More articles from Life Sciences:

nachricht New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego

nachricht Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Gran Chaco: Biodiversity at High Risk

17.01.2018 | Ecology, The Environment and Conservation

Only an atom thick: Physicists succeed in measuring mechanical properties of 2D monolayer materials

17.01.2018 | Physics and Astronomy

Fraunhofer HHI receives AIS Technology Innovation Award 2018 for 3D Human Body Reconstruction

17.01.2018 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>