Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists open doors to diagnosis of emphysema

03.08.2009
EMBL development may provide powerful new test for inflammatory lung diseases

Chronic inflammatory lung diseases like chronic bronchitis and emphysema are a major global health problem, and the fourth leading cause of death and disability in developed countries, with smoking accounting for 90% of the risk for developing them.

Work by scientists at the European Molecular Biology Laboratory (EMBL) and its Molecular Medicine Partnership Unit (MMPU) with the University of Heidelberg, Germany, has shed new light on the underlying disease process of emphysema using a technique which could in future be adapted for use in diagnosis. The study is published today in Nature Chemical Biology.

The researchers present a new strategy for testing the activity of MMP12, an enzyme known to be involved in the development of emphysema. Emphysema is characterised by the damage and destruction of the alveoli, the tiny air-sacs of the lungs that are crucial for respiration and uptake of oxygen from the air.

Cigarette smoke and other irritants activate immune cells, like macrophages, in the lungs to destroy the foreign material, and chronic exposure causes inflammation. MMP12 is an enzyme secreted by macrophages which usually helps them to break down the extracellular matrix (the complex network of proteins and fibers that surround and support the cells of the body), a process important for normal wound healing. However, over-stimulation of macrophages by irritants leads to build up of excess MMP12, which starts to damage the delicate structure of the small airspaces of the lungs, eventually leading to emphysema.

“We developed a tool which, for the first time, allows us to study MMP12 activity in specific cells, as if we were actually looking inside the lungs,” says Carsten Schultz, whose group carried out the research at EMBL.

The researchers designed a special fluorescent probe that essentially allows MMP12 activity in macrophages to be quantified by the amount of fluorescence they take up. Applying this test to samples of lung cells from a mouse model of acute lung inflammation showed that MMP12 activity in macrophages was indeed increased.

Although the study was performed in mice, the researchers hope that in future it will be possible to adapt the test for use in patients. “It would allow us to use MMP12 as a biomarker to monitor disease evolution and the risk of emphysema formation. It could also serve to examine the response to therapeutic interventions in patients with inflammatory lung diseases,” says Marcus Mall, group leader at the Children's Hospital at the University of Heidelberg.

The EMBL and University researchers hope that the new testing strategy can be extended to other enzymes involved in lung inflammation and that, with a better picture of the processes underlying these diseases, future treatments could be more specific, reducing the side-effects often caused by broad spectrum treatments.

Anna-Lynn Wegener
Press Officer
EMBL
Meyerhofstrasse 1
D-69117 Heidelberg
Tel: +49 6221 387452
Fax: +49 6221 387525
anna.wegener@embl.de

Anna-Lynn Wegener | EMBL
Further information:
http://www.embl.org
http://www.embl.de/aboutus/news/pr_archive/2009/090802_Heidelberg/index.html

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>