New findings in mitochondrial biology thoroughly change the idea scientists had for 20 years on the role and importance of the protein MTERF1. For the first time, Max Planck researcher Mügen Terzioglu investigated in vivo what was up to now only explored in cell culture. Using the mouse as a model organism, she made a surprising discovery:
MTERF1 does after all not play the key role in mitochondrial transcription and translation that was hitherto ascribed to it. Terzioglu’s findings will change the way we look at the regulation of mitochondrial function in the cell.With her study, the young researcher demonstrates the way science often works: Long-standing research findings might be overthrown by surprising new insights, thus necessitating future projects with regard to related questions to take on a whole new direction. Mügen Terzioglu is a researcher in the department „Mitochondrial Biology“, headed by Director Nils-Göran Larsson at the Max Planck Institute (MPI) for Biology of Ageing in Cologne. She carried out her project with an international team of scientists at the MPI and at the Karolinska Institute in Stockholm.
“Up to now, the role of MTERF1 was only investigated in vitro, using cell culture. And for two decades, this protein was thought to play a crucial role in the regulation of transcription, eventually acting as a key regulator for mitochondrial protein synthesis in mammals“, explains Mügen Terzioglu. “However, by engineering an appropriate mouse model for the first time, we have now learned that this is not the case. That was actually quite a surprise to us.“ It also illustrates the fact that in vitro systems like cell culture can only to a certain extent represent a natural physiological condition. Consequently, the insights gained in vitro must always be verified in vivo.
Mügen Terzioglu’s findings will change the way we look at proteins and understand their roles in the cell. In particular, a new perspective opens up to better understand the regulation in mitochondrial transcription and translation as well as the stability of the mitochondrial transcripts and their metabolism.Original publication:
Sabine Dzuck | Max-Planck-Institut
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy