Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Link DNA to Nanostructures

22.09.2011
Work May Pave Way for Development of New Materials

Assembly of nanostructures using DNA may lead to the production of new materials with a wide range of applications from electronics to tissue engineering. Researchers in the Institute for Nanoscience and Engineering at the University of Arkansas have produced building blocks for such material by controlling the number, placement and orientation of DNA linkers on the surface of colloidal nanoparticles.

Their work is featured as the “hot paper” in the current issue of Angewandte Chemie International Edition, the weekly scientific journal of the German Chemical Society.

“We have demonstrated a strategy to place ‘DNA linkers’ on a nanoparticle at specific angles relative to each other so that we may produce building blocks with well-defined arrangements of DNA in all dimensions,” said Jin-Woo Kim, professor of biological engineering. “The specific number and orientation of DNA strands on the nanoparticles allow greater control over the ultimate shape of nanostructures.”

DNA linkers are areas on the nanoparticles that functionally allow connection with other nanoparticles. In this case, connection is achieved through a type of DNA hybridization reaction.

The simple and sustainable strategy involves attaching strands of DNA to functionalized nanoparticles one strand after the other rather than all at the same time. The nanoparticle with the first strand serves as the starting material for the second strand. The nanoparticle with these two strands together serves as the starting material for the third, and so on. In addition to facilitating greater control over the shape of the structure, assembling in this sequential manner renders the process more reproducible and scalable, which helps with the assembly of complex, hybrid nanoscale architectures at all scales and in all dimensions.

The building blocks, which the researchers call “nBLOCKs,” remained stable under volatile conditions. They exhibited chemical stability and water solubility during ligand replacement reactions. There were no apparent changes in physical and chemical properties when the building blocks were stored at 4 degrees Celsius for at least a month. Such promising stability shows high potential for their practical application. The researchers continue working on further optimizing their physical and chemical stability.

Kim said the building strategy can be generalized for other types of nanoparticles, meaning that construction of other types of building blocks with specific, desired functions may be achieved. The technology has the potential to transform many fields of research, including biology, medicine, chemistry, physics, materials science and engineering.

The research was supported by the National Science Foundation, the University of Arkansas Division of Agriculture and the Arkansas Biosciences Institute.

The work was a multidisciplinary, collaborative effort with Russell Deaton, professor of computer science and computer engineering. Jeong-Hwan Kim, postdoctoral associate at the Bio/Nano Technology Laboratory, also made a significant contribution to the project.

Jin-Woo Kim is a professor in the Dale Bumpers College of Agricultural, Food and Life Sciences and the College of Engineering. He works in the Institute for Nanoscience and Engineering at the University of Arkansas and directs the Bio/Nano Technology Laboratory.

CONTACTS:
Jin-Woo Kim, professor
Biological and Agricultural Engineering
479-575-3402, jwkim@uark.edu
Matt McGowan, science and research communications officer
University Relations
479-575-4246, dmcgowa@uark.edu

Matt McGowan | Newswise Science News
Further information:
http://www.uark.edu

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>