Newly identified markers of inflammation have potential to contribute to better understanding of heart disease
Researchers at the Intermountain Medical Center Heart Institute in Murray, Utah, have discovered that elevated levels of two recently identified proteins in the body are inflammatory markers and indicators of the presence of cardiovascular disease.
These newly identified markers of inflammation, GlycA and GlycB, have the potential to contribute to better understanding of the inflammatory origins of heart disease and may be used in the future to identify a heart patient's future risk of suffering a heart attack, stroke, or even death.
Inflammation occurs in the body in response to tissue damage, irritation, or infection. Inflammation is often associated with injury (i.e., sprained ankle), infection (i.e., strep throat), and auto-immune diseases (i.e., rheumatoid arthritis). However, it has been shown that inflammation is also a risk factor for heart disease.
"There are at least two benefits evident from this study," said J. Brent Muhlestein, MD, lead researcher and co-director of cardiovascular research at the Intermountain Medical Center Heart Institute. "First, a new marker of heart attack or stroke may help us to more effectively identify which patients are at risk. Second, now that we know GlycA and GlycB are important predictors of heart disease, we'll seek to understand more about the physiology of these proteins – what causes them to increase and how we can we treat elevated levels."
Levels of GlycA and GlycB were determined from a blood test called nuclear magnetic resonance (NMR) spectroscopy, which was developed to determine the number of lipid particles contained in different cholesterol parameters.
Testing for GlycA and GlycB by NMR spectroscopy uses signals that arise from the binding of glucose molecules to a variety of circulating inflammatory proteins, especially fibrinogen, α1-antichymotrypsin, haptoglobin-1, α1-antitrypsin, complement C3 and α1-acid glycoprotein.
Like C-reactive protein, one of the most well-known and studied inflammatory markers shown to be associated with cardiovascular disease, GlycA and GlycB are acute phase proteins with plasma concentrations that increase or decrease in response to changes in the levels of inflammation throughout the body.
This is one of the first studies ever to evaluate the association of GlycA and GlycB to cardiovascular disease. In this study, almost 3,000 patients who underwent heart catheterization to determine the presence of coronary artery disease with a minimum of five years of follow-up were evaluated.
Of the 48 percent of heart patients who died, suffered a heart attack, stroke, or heart failure during follow-up, the majority had significantly higher baseline levels of GlycA and GlycB. Specifically, those with levels in the top 25 percent were more than 30 percent more likely to have an adverse cardiovascular event compared to those with levels in the lowest 25 percent, even after other risk factors were taken into account.
"The next step will be to determine how GycA and GlycB correlate with, or are independent of, other common inflammatory markers like C-reactive protein," said Dr. Muhlestein.
Other members of the Intermountain Medical Center Heart Institute research team include: Jeffrey L. Anderson, MD, and Heidi T. May, PhD, MSPH.
Jess C. Gomez | EurekAlert!
Killer sea snail a target for new drugs
07.07.2015 | University of Queensland
First images of dolphin brain circuitry hint at how they sense sound
07.07.2015 | Emory Health Sciences
When a duck paddles across a pond or a supersonic plane flies through the sky, it leaves a wake in its path. Wakes occur whenever something is traveling...
Researchers explore ultrafast control of magnetism across interfaces: A new study discovers how the sudden excitation of lattice vibrations in a crystal can trigger a change of the magnetic properties of an atomically-thin layer that lies on its surface.
A research team, led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter at CFEL in Hamburg, the University of Oxford, and the...
Wind turbines could be installed under some of the biggest bridges on the road network to produce electricity. So it is confirmed by calculations carried out by a European researchers team, that have taken a viaduct in the Canary Islands as a reference. This concept could be applied in heavily built-up territories or natural areas with new constructions limitations.
The Juncal Viaduct, in Gran Canaria, has served as a reference for Spanish and British researchers to verify that the wind blowing between the pillars on this...
New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions
A new technique pioneered at the U.S. Department of Energy's Brookhaven National Laboratory reveals atomic-scale changes during catalytic reactions in real...
Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and a half billion years ago.
Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and...
25.06.2015 | Event News
16.06.2015 | Event News
11.06.2015 | Event News
07.07.2015 | Physics and Astronomy
07.07.2015 | Earth Sciences
07.07.2015 | Physics and Astronomy