This nutrient sensing pathway, which is described in the current on-line issue of Cell Metabolism, may also have implications for the health benefits of polyphenols containing foods against fatty liver, hyperlipidemia, and atherosclerosis associated with obesity and type 2 diabetes.
Although it is well known that elevated serum cholesterol and triglyceride levels and fatty liver are caused by increased hepatic lipid synthesis and/or decreased lipid clearance in patients with obesity and diabetes, the underlying mechanistic pathways of these changes remains unknown.
The master regulators of lipid metabolism that were studied are called AMPK and SREBP. The researchers used a molecular biology approach, cell culture system and animal models to indicate that dysregulation of AMPK, an energy sensor, and SREBP, a protein that is important regulator for lipid biosynthesis, are affected in obesity. Mice fed a diet with high fat and high sucrose became obese and had insulin resistance and elevated circulating levels of cholesterol and triglyceride which led to accelerated atherosclerosis. In contrast, dietary supplementation with S17834, a polyphenol, significantly improved the metabolic disorder, lipid levels and atherosclerosis.
“Our findings suggest that AMPK suppression and SREBP activation are a root cause of fatty liver and hyperlipidemia in type 2 diabetes and its associated vascular complications such as atherosclerosis,” said senior author Mengwei Zang, MD, PhD, an assistant professor of medicine at BUSM.
According to the researchers the potential health benefits of polyphenols have been gaining increasing interest. “In our studies, AMPK is potently and persistently activated by polyphenols including the natural compound resveratrol, which is present in red wine, grapes and green tea, as well as the synthetic polyphenol S17834, which is a drug candidate provided by Servier Pharmaceutical Company,” explained Zang.
“AMPK directly suppresses SREBP via its phosphorylation, inhibiting the activity of its target lipogenic enzymes in the liver, and accounting for the protective effects of the polyphenols on fatty liver, blood lipids and diabetic atherosclerosis,” she added.
The researchers believe these findings may lead to the development of new drugs that could stop or slow diabetes progression or improve current treatments.
Gina DiGravio | EurekAlert!
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
25.10.2016 | Earth Sciences
25.10.2016 | Power and Electrical Engineering
25.10.2016 | Process Engineering