Big perspectives for patientsHe believes that once one has defined how the complement system works, it will be possible to manipulate it:
MASP-1 and the lectin pathway
Behind the discovery of the central role of MASP-1 in the complement system is, apart from Soeren Egedal Degn, also the Aarhus professors Jens Chr. Jensenius and Steffen Thiel, who are considered international experts in the field. They have previously discovered the four other known proteins related to MASP-1, namely MASP-2, MASP-3, MAp19 and MAp44. Together, these proteins make up a central part of the activation pathway of complement known as the lectin pathway. The research group in Aarhus, which also includes the laboratory technicians Lisbeth Jensen and Annette G. Hansen, has been central in the elucidation of the lectin pathway through the past 15 years.
The enzyme MASP-1 is able to efficiently auto-activate, for example when it "senses" a bacterium. It then activates MASP-2, which in turn activates the rest of the complement system in a cascade-like manner, where a long list of enzymes sequentially activate each other - much like dominoes. The result is a signal to immune cells to home to the area in the body, where the system is activated, and to kill the intruding bacteria. The bacteria are also covered in "molecular tags", making it easier for the immune cells to recognize and efficiently engulf them. Finally, the complement system directly "punches holes" in the bacteria, by forming pore-like structures in their membranes.
This work has been supported by the Lundbeck Foundation, The Novo Nordic Foundation, as well as the Danish Council for Independent Research - Medical Sciences. Soeren Egedal Degn is employed at the Department of Biomedicine, Aarhus University, through a postdoctoral fellowship from the Carlsberg Foundation.
A Fluttering Accordion
04.08.2015 | Friedrich-Schiller-Universität Jena
Molecular Spies to Fight Cancer - Procedure for improving tumor diagnosis successfully tested
03.08.2015 | Helmholtz-Zentrum Dresden-Rossendorf
Continuing current carbon dioxide (CO2) emission trends throughout this century and beyond would leave a legacy of heat and acidity in the deep ocean. These...
Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.
The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...
Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.
What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...
Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.
The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
04.08.2015 | Event News
23.07.2015 | Event News
10.07.2015 | Event News
05.08.2015 | Physics and Astronomy
05.08.2015 | Ecology, The Environment and Conservation
05.08.2015 | Earth Sciences