Big perspectives for patientsHe believes that once one has defined how the complement system works, it will be possible to manipulate it:
MASP-1 and the lectin pathway
Behind the discovery of the central role of MASP-1 in the complement system is, apart from Soeren Egedal Degn, also the Aarhus professors Jens Chr. Jensenius and Steffen Thiel, who are considered international experts in the field. They have previously discovered the four other known proteins related to MASP-1, namely MASP-2, MASP-3, MAp19 and MAp44. Together, these proteins make up a central part of the activation pathway of complement known as the lectin pathway. The research group in Aarhus, which also includes the laboratory technicians Lisbeth Jensen and Annette G. Hansen, has been central in the elucidation of the lectin pathway through the past 15 years.
The enzyme MASP-1 is able to efficiently auto-activate, for example when it "senses" a bacterium. It then activates MASP-2, which in turn activates the rest of the complement system in a cascade-like manner, where a long list of enzymes sequentially activate each other - much like dominoes. The result is a signal to immune cells to home to the area in the body, where the system is activated, and to kill the intruding bacteria. The bacteria are also covered in "molecular tags", making it easier for the immune cells to recognize and efficiently engulf them. Finally, the complement system directly "punches holes" in the bacteria, by forming pore-like structures in their membranes.
This work has been supported by the Lundbeck Foundation, The Novo Nordic Foundation, as well as the Danish Council for Independent Research - Medical Sciences. Soeren Egedal Degn is employed at the Department of Biomedicine, Aarhus University, through a postdoctoral fellowship from the Carlsberg Foundation.
New type of photosynthesis discovered
17.06.2018 | Imperial College London
New ID pictures of conducting polymers discover a surprise ABBA fan
17.06.2018 | University of Warwick
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
18.06.2018 | Materials Sciences
18.06.2018 | Physics and Astronomy
15.06.2018 | Materials Sciences