Big perspectives for patientsHe believes that once one has defined how the complement system works, it will be possible to manipulate it:
MASP-1 and the lectin pathway
Behind the discovery of the central role of MASP-1 in the complement system is, apart from Soeren Egedal Degn, also the Aarhus professors Jens Chr. Jensenius and Steffen Thiel, who are considered international experts in the field. They have previously discovered the four other known proteins related to MASP-1, namely MASP-2, MASP-3, MAp19 and MAp44. Together, these proteins make up a central part of the activation pathway of complement known as the lectin pathway. The research group in Aarhus, which also includes the laboratory technicians Lisbeth Jensen and Annette G. Hansen, has been central in the elucidation of the lectin pathway through the past 15 years.
The enzyme MASP-1 is able to efficiently auto-activate, for example when it "senses" a bacterium. It then activates MASP-2, which in turn activates the rest of the complement system in a cascade-like manner, where a long list of enzymes sequentially activate each other - much like dominoes. The result is a signal to immune cells to home to the area in the body, where the system is activated, and to kill the intruding bacteria. The bacteria are also covered in "molecular tags", making it easier for the immune cells to recognize and efficiently engulf them. Finally, the complement system directly "punches holes" in the bacteria, by forming pore-like structures in their membranes.
This work has been supported by the Lundbeck Foundation, The Novo Nordic Foundation, as well as the Danish Council for Independent Research - Medical Sciences. Soeren Egedal Degn is employed at the Department of Biomedicine, Aarhus University, through a postdoctoral fellowship from the Carlsberg Foundation.
Two decades of training students and experts in tracking infectious disease
27.11.2015 | Hochschule für Angewandte Wissenschaften Hamburg
Increased carbon dioxide enhances plankton growth, opposite of what was expected
27.11.2015 | Bigelow Laboratory for Ocean Sciences
Planet Earth experienced a global climate shift in the late 1980s on an unprecedented scale, fuelled by anthropogenic warming and a volcanic eruption, according to new research published this week.
Scientists say that a major step change, or ‘regime shift’, in the Earth’s biophysical systems, from the upper atmosphere to the depths of the ocean and from...
The Fraunhofer Institute for Solar Energy Systems ISE has installed 70 photovoltaic modules on the outer façade of one of its lab buildings. The modules were...
Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.
In comparison to other organs, the human brain has the highest energy requirements. The supply of energy for nerve cells and the particular role of lactic acid...
In laser material processing, the simulation of processes has made great strides over the past few years. Today, the software can predict relatively well what will happen on the workpiece. Unfortunately, it is also highly complex and requires a lot of computing time. Thanks to clever simplification, experts from Fraunhofer ILT are now able to offer the first-ever simulation software that calculates processes in real time and also runs on tablet computers and smartphones. The fast software enables users to do without expensive experiments and to find optimum process parameters even more effectively.
Before now, the reliable simulation of laser processes was a job for experts. Armed with sophisticated software packages and after many hours on computer...
Researchers at Heidelberg University have devised a new way to study the phenomenon of magnetism. Using ultracold atoms at near absolute zero, they prepared a...
25.11.2015 | Event News
17.11.2015 | Event News
21.10.2015 | Event News
27.11.2015 | Press release
27.11.2015 | Life Sciences
27.11.2015 | Materials Sciences