Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers develop software tool for cancer genomics

27.08.2013
Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.

Xing Hua, Ph.D., postdoctoral fellow in biostatistics at the National Cancer Institute, and a former visiting scholar at MCW, is the first author of the paper. Yan Lu, Ph.D., assistant professor of physiology, is corresponding author; and Pengyuan Liu, Ph.D., associate professor of physiology at MCW, is the co-corresponding author.

Cancers are caused by the accumulation of genomic alterations, or mutations. Genomic sequencing identifies two specific types of mutations: driver mutations, which are responsible for cancer, and passenger mutations, which are irrelevant to tumor development. A major challenge in cancer genome sequencing is discriminating between the two types of mutations.

The authors incorporated statistical methods and bioinformatics tools into the computational tool DrGaP, which stands for "Driver Genes and Pathways."

"DrGaP is immediately applicable to cancer genome sequencing studies and will lead a more complete identification of altered driver genes and driver signaling pathways in cancer," said Dr. Liu. "Biological knowledge of the mutation process is fully integrated into the models, and provides several significant improvements and increased power over current methods."

The researchers note that DrGaP not only recaptured a large majority of driver genes previously reported in other studies, but also identified much longer list of additional candidate genes whose mutations may be linked to cancer. This data demonstrates the extreme complexity of tumor cells and has important implications in targeted cancer therapy.

Other authors of the paper include Haiming Xu, Ph.D., MCW; Yaning Yang, Ph.D., University of Science and Technology of China; and Jun Zhu, Ph.D., Institute of Bioinformatics, Zheijiang University in Zhejiang, China.

Maureen Mack | EurekAlert!
Further information:
http://www.mcw.edu

More articles from Life Sciences:

nachricht Blowfly maggots provide physical evidence for forensic cases
02.09.2014 | Universiti Teknologi MARA (UiTM)

nachricht Surprising new role for calcium in sensing pain
02.09.2014 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

IT security in the digital society

27.08.2014 | Event News

Understanding the brain—neuroscientists meet in Göttingen

27.08.2014 | Event News

MEDICA EDUCATION CONFERENCE: Bessere Behandlung dank Biomarker

21.08.2014 | Event News

 
Latest News

A smart fluorescent antenna for Wi-Fi applications

02.09.2014 | Power and Electrical Engineering

Blowfly maggots provide physical evidence for forensic cases

02.09.2014 | Life Sciences

Single laser stops molecular tumbling motion instantly

02.09.2014 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>