Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers capture bacterial infection on film

29.07.2009
Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host.

Whilst most studies of bacterial infection are done after the death of the infected organism, this system developed by scientists at the University of Bath and University of Exeter is the first to follow the progress of infection in real-time with living organisms.

The researchers used developing fruit fly embryos as a model organism, injecting fluorescently tagged bacteria into the embryos and observing their interaction with the insect’s immune system using time-lapse confocal microscopy.

The researchers can also tag individual bacterial proteins to follow their movement and determine their specific roles in the infection process.

The scientists are hoping to use this system in the future with human pathogens such as Listeria and Trypanosomes. By observing how these bacteria interact with the immune system, researchers will gain a better understanding of how they cause an infection and could eventually lead to better antibacterial treatments.

Dr Will Wood, Research Fellow in the Department of Biology & Biochemistry at the University of Bath, explained: “Cells often behave very differently once they have been taken out of their natural environment and cultured in a petri dish.

“In the body, immune surveillance cells such as hemocytes (or macrophages in vertebrates) are exposed to a battery of signals from different sources. The cells integrate these signals and react to them accordingly.

“Once these cells are removed from this complex environment and cultured in a petri dish these signals are lost. Therefore it is really important to study whole organisms to fully understand how bacteria interact with their host.”

Dr Nick Waterfield, co-author on the study and Research Officer at the University of Bath, said: “To be able to film the microscopic battle between single bacterial cells and immune cells in a whole animal and in real time is astounding.

“It will ultimately allow us to properly understand the dynamic nature of the infection process.”

Professor Richard Ffrench-Constant, Professor of Molecular Natural History at the University of Exeter, added: “For the first time this allows us to actually examine infection in real time in a real animal - it’s a major advance!”

The study, published in PLoS Pathogens, was funded by the Wellcome Trust and the Biotechnology & Biological Sciences Research Council.

Vicky Just | EurekAlert!
Further information:
http://www.bath.ac.uk

More articles from Life Sciences:

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
21.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
21.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>