Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers capture bacterial infection on film

29.07.2009
Researchers have developed a new technique that allows them to make a movie of bacteria infecting their living host.

Whilst most studies of bacterial infection are done after the death of the infected organism, this system developed by scientists at the University of Bath and University of Exeter is the first to follow the progress of infection in real-time with living organisms.

The researchers used developing fruit fly embryos as a model organism, injecting fluorescently tagged bacteria into the embryos and observing their interaction with the insect’s immune system using time-lapse confocal microscopy.

The researchers can also tag individual bacterial proteins to follow their movement and determine their specific roles in the infection process.

The scientists are hoping to use this system in the future with human pathogens such as Listeria and Trypanosomes. By observing how these bacteria interact with the immune system, researchers will gain a better understanding of how they cause an infection and could eventually lead to better antibacterial treatments.

Dr Will Wood, Research Fellow in the Department of Biology & Biochemistry at the University of Bath, explained: “Cells often behave very differently once they have been taken out of their natural environment and cultured in a petri dish.

“In the body, immune surveillance cells such as hemocytes (or macrophages in vertebrates) are exposed to a battery of signals from different sources. The cells integrate these signals and react to them accordingly.

“Once these cells are removed from this complex environment and cultured in a petri dish these signals are lost. Therefore it is really important to study whole organisms to fully understand how bacteria interact with their host.”

Dr Nick Waterfield, co-author on the study and Research Officer at the University of Bath, said: “To be able to film the microscopic battle between single bacterial cells and immune cells in a whole animal and in real time is astounding.

“It will ultimately allow us to properly understand the dynamic nature of the infection process.”

Professor Richard Ffrench-Constant, Professor of Molecular Natural History at the University of Exeter, added: “For the first time this allows us to actually examine infection in real time in a real animal - it’s a major advance!”

The study, published in PLoS Pathogens, was funded by the Wellcome Trust and the Biotechnology & Biological Sciences Research Council.

Vicky Just | EurekAlert!
Further information:
http://www.bath.ac.uk

More articles from Life Sciences:

nachricht Show me your leaves - Health check for urban trees
12.12.2017 | Gesellschaft für Ökologie e.V.

nachricht Liver Cancer: Lipid Synthesis Promotes Tumor Formation
12.12.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

Liver Cancer: Lipid Synthesis Promotes Tumor Formation

12.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>