Although precise data isn’t available, LABC may account for 50 percent or more of breast cancers among women in developing countries, and 30 percent of breast cancers among socially disadvantaged and minority women in the United States. This type of cancer is defined by a large tumor that is about 2 inches or larger in diameter, about the size of a plum, when first diagnosed. The cancer may have spread into surrounding lymph nodes or other tissues. However, it hasn’t yet spread to more distant areas in the body.
Without treatment, fewer than 20 percent of patients with LABC are living five years after their diagnosis. Unfortunately, even with appropriate treatments, this cancer is deadlier than other types of breast cancer that are detected earlier.
With funding from the Breast Cancer Research Foundation and the Department of Defense, Robert J. Schneider, Ph.D., the Albert B. Sabin Professor of Molecular Pathogenesis, and Silvia C. Formenti, M.D., the Sandra and Edward H. Meyer Professor of Radiation Oncology and Chairwoman of Radiation Oncology, and their colleagues at NYU School of Medicine have made LABC the focus of a coordinated effort to understand the disease.
“This disease has not been sufficiently studied, in part because of the social, psychological, economic, and cultural barriers that may stand in the way of obtaining care,” says Dr. Formenti.
“Our study shows that an unusual molecular switch occurs that is essential for the development of these large tumors. We think that this switch could be a target for new therapies,” says Dr. Schneider.
The new study is published in the November 9, 2007 issue of the journal Molecular Cell.
Drs. Schneider and Formenti led the new study which found that two molecules were unusually abundant or “overexpressed” specifically in locally advanced breast cancers. Further analysis in mice revealed that the molecules orchestrated a switch in the use of messenger RNA, a kind of ferry service that carries information for making proteins. This switch, the researchers found, occurs when tumors become starved for oxygen, a condition known as hypoxia. The switch permits the selective expression of proteins that are required for tumors to carry out angiogenesis, the process of developing a blood supply. It also enables tumors to grow to a large size and to progress.
“The identification of the molecular switch and its importance for development of locally advanced breast cancer reveals realistic targets for the development of new therapeutics to block tumor angiogenesis and progression in breast and possibly other cancers,” says Dr. Schneider.
The authors of this study are: Drs. Formenti and Schneider; Ksenia Karpisheva; Steve Braunstein; Carolina Pola; Judith Goldberg; Tsivia Hochman; Herman Yee; Joan Cangiarella; and Rezina Arju. All are affiliated with NYU School of Medicine.
Pamela McDonnell | EurekAlert!
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy