Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The difference between fish and humans: scientists answer century old developmental question

11.10.2007
Embryologists at UCL (University College London) have helped solve an evolutionary riddle that has been puzzling scientists for over a century. They have identified a key mechanism in the initial stages of an embryo's development that helps differentiate more highly evolved species, including humans, from less evolved species, such as fish. The findings of the research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), were published online today by the journal Nature.

Early on in development, the mass of undifferentiated cells that make up the embryo must take the first steps in deciding how to arrange themselves into component parts to eventually go on to form a fully developed body. This is a process known as 'gastrulation'. During this stage, the cells group into three layers, the first is the 'ectoderm' which then in turn generates the 'mesoderm' and 'endoderm' layers.

In higher vertebrates, such as mammals and birds, the mesoderm and endoderm are generated from an axis running through the centre of the embryo. However, in lower vertebrates, such as amphibians and fish, the two layers are generated around the edge of the embryo.

Using chicken eggs and a state-of-the-art imaging device which can reveal how cells move in three dimensions, the researchers demonstrated a key difference in the way gastrulation occurs between higher vertebrate species and less evolutionarily advanced animals. They discovered that the reason why higher vertebrates form their axis at the midline of the embryo is because during evolution they acquired a new mechanism of "cell intercalation" which positions the axis at the midline. They also discovered the molecules used by the embryo to control these cell movements.

... more about:
»Development »Embryo »century »difference »vertebrate

Scientists have been speculating for over a century on the difference between the embryonic development of higher vertebrates and lower vertebrates, to help answer how the simple cell structure of an embryo goes on to form the various highly complex bodies of different species. Research leader Prof Claudio Stern explains: "This is a significant find as it is a clear difference between the embryonic development of more advanced species and less advanced species. It suggests that higher vertebrates must have developed this mechanism later on in the history of animal evolution.

In humans this process occurs during week 3 of embryonic development, and forms the cut-off point for scientific research on human embryos in the UK.

The research was funded by BBSRC with support from the Medical Research Council (MRC) and the European Union FP6 Network of Excellence 'Cells into Organs'.

Michelle Kilfoyle | alfa
Further information:
http://www.bbsrc.ac.uk

Further reports about: Development Embryo century difference vertebrate

More articles from Life Sciences:

nachricht Scientists spin artificial silk from whey protein
24.01.2017 | Deutsches Elektronen-Synchrotron DESY

nachricht Choreographing the microRNA-target dance
24.01.2017 | UT Southwestern Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>