Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCD researchers discover blood test to predict response to arthritis therapies

26.09.2007
UCD researchers have shown for the first time that a simple blood test can predict those patients suffering from inflammatory arthritis who will respond to treatment at an early stage.

The group of clinicians and scientists based in UCD Conway Institute of Biomolecular & Biomedical Research and St Vincent’s University Hospital, working with collaborators from McGill University, Montreal, have published their findings in the current issue of the leading scientific journal, Arthritis and Rheumatism.

Rheumatoid arthritis and psoriatic arthritis are forms of progressive inflammatory arthritis that cause pain and progressive destruction of the joints. These diseases can be treated using drugs called tumour necrosis factor alpha (TNFa) inhibitors, which prevent damage and limit disability in arthritis patients. The extent of joint destruction can be measured by x-ray but this visible progression develops over months and years and is not suitable to measure the efficiency of treatment to reduce joint damage over a short period.

Dr Ronan Mullan, a medical PhD student with the arthritis translational research group led by Professor Douglas Veale and Dr Ursula Fearon, funded by The Health Research Board and Science Foundation Ireland, outlined the findings of this clinical study that measured particles of cartilage collagen in the blood after the start of treatment with anti-TNFa drugs. The early changes seen in the blood levels of these collagen biomarkers at 4 weeks corresponded to the visible joint destruction seen on x-ray after one year.

‘We are very excited about the results of this research, which clearly show that collagen biomarkers may be valuable early indicators of response to arthritis treatment’, said Professor Douglas Veale. ‘This new blood test could rapidly identify patients who are at risk of their disease progressing despite ongoing therapy. It would be a valuable diagnostic tool for clinicians’.

Rheumatoid arthritis is the most widespread form of inflammatory arthritis affecting more than 80,000 people in Ireland today. It can severely impact on the quality of life of patients and direct medical costs have been estimated at €30,000 per annum for each patient. An early indicator of likely response to new and expensive treatments would not only benefit the patient but the health service generally.

This research group led by Professor Douglas Veale and Dr Ursula Fearon are part of the newly formed, Dublin Academic Health Care (DAHC); Ireland’s first academic medical centre.

Elaine Quinn | alfa
Further information:
http://www.ucd.ie
http://www3.interscience.wiley.com/cgi-bin/abstract/116311017/ABSTRACT?CRETRY=1&SRETRY=0

Further reports about: Arthritis Collagen Treatment Veale destruction inflammatory

More articles from Life Sciences:

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>