Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCD researchers discover blood test to predict response to arthritis therapies

26.09.2007
UCD researchers have shown for the first time that a simple blood test can predict those patients suffering from inflammatory arthritis who will respond to treatment at an early stage.

The group of clinicians and scientists based in UCD Conway Institute of Biomolecular & Biomedical Research and St Vincent’s University Hospital, working with collaborators from McGill University, Montreal, have published their findings in the current issue of the leading scientific journal, Arthritis and Rheumatism.

Rheumatoid arthritis and psoriatic arthritis are forms of progressive inflammatory arthritis that cause pain and progressive destruction of the joints. These diseases can be treated using drugs called tumour necrosis factor alpha (TNFa) inhibitors, which prevent damage and limit disability in arthritis patients. The extent of joint destruction can be measured by x-ray but this visible progression develops over months and years and is not suitable to measure the efficiency of treatment to reduce joint damage over a short period.

Dr Ronan Mullan, a medical PhD student with the arthritis translational research group led by Professor Douglas Veale and Dr Ursula Fearon, funded by The Health Research Board and Science Foundation Ireland, outlined the findings of this clinical study that measured particles of cartilage collagen in the blood after the start of treatment with anti-TNFa drugs. The early changes seen in the blood levels of these collagen biomarkers at 4 weeks corresponded to the visible joint destruction seen on x-ray after one year.

‘We are very excited about the results of this research, which clearly show that collagen biomarkers may be valuable early indicators of response to arthritis treatment’, said Professor Douglas Veale. ‘This new blood test could rapidly identify patients who are at risk of their disease progressing despite ongoing therapy. It would be a valuable diagnostic tool for clinicians’.

Rheumatoid arthritis is the most widespread form of inflammatory arthritis affecting more than 80,000 people in Ireland today. It can severely impact on the quality of life of patients and direct medical costs have been estimated at €30,000 per annum for each patient. An early indicator of likely response to new and expensive treatments would not only benefit the patient but the health service generally.

This research group led by Professor Douglas Veale and Dr Ursula Fearon are part of the newly formed, Dublin Academic Health Care (DAHC); Ireland’s first academic medical centre.

Elaine Quinn | alfa
Further information:
http://www.ucd.ie
http://www3.interscience.wiley.com/cgi-bin/abstract/116311017/ABSTRACT?CRETRY=1&SRETRY=0

Further reports about: Arthritis Collagen Treatment Veale destruction inflammatory

More articles from Life Sciences:

nachricht Repairing damaged hearts with self-healing heart cells
22.08.2017 | National University Health System

nachricht Biochemical 'fingerprints' reveal diabetes progression
22.08.2017 | Umea University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Cholesterol-lowering drugs may fight infectious disease

22.08.2017 | Health and Medicine

Meter-sized single-crystal graphene growth becomes possible

22.08.2017 | Materials Sciences

Repairing damaged hearts with self-healing heart cells

22.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>